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Morphometric Evaluation of Preeclamptic Placenta Using Light Microscopic Images
Author
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Deficient trophoblast invasion and anomalies in placental development generally lead to preeclampsia (PE) but the inter-relationship between placental function and morphology in PE still remains unknown.
The aim of this study was to evaluate the morphometric features of placental villi and capillaries in preeclamptic and normal placentae.
The study included light microscopic images of placental tissue sections of 40 preeclamptic and 35 normotensive pregnant women.
Preprocessing and segmentation of these images were performed to characterize the villi and capillaries.
Fisher’s linear discriminant analysis (FLDA), hierarchical cluster analysis (HCA), and principal component analysis (PCA) were applied to identify the most significant placental (morphometric) features from microscopic images.
A total of 10 morphometric features were extracted, of which the villous parameters were significantly altered in PE.
FLDA identified 5 highly significant morphometric features (>90% overall discrimination accuracy).
Two large subclusters were clearly visible in HCA based dendrogram.
PCA returned three most significant principal components cumulatively explaining 98.4% of the total variance based on these 5 significant features.
Hence, quantitative microscopic evaluation revealed that placental morphometry plays an important role in characterizing PE, where the villous is the major component that is affected.
American Psychological Association (APA)
Mukherjee, Rashmi. 2014. Morphometric Evaluation of Preeclamptic Placenta Using Light Microscopic Images. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-461063
Modern Language Association (MLA)
Mukherjee, Rashmi. Morphometric Evaluation of Preeclamptic Placenta Using Light Microscopic Images. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-461063
American Medical Association (AMA)
Mukherjee, Rashmi. Morphometric Evaluation of Preeclamptic Placenta Using Light Microscopic Images. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-461063
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461063