ROS and RNS Signaling in Heart Disorders : Could Antioxidant Treatment Be Successful?
Author
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
There is not too much success in the antioxidant treatment of heart deceases in humans.
However a new approach is now developed that suggests that depending on their structures and concentrations antioxidants can exhibit much more complicated functions in many pathological disorders.
It is now well established that physiological free radicals superoxide and nitric oxide together with their derivatives hydrogen peroxide and peroxynitrite (all are named reactive oxygen species (ROS) and reactive nitrogen species (RNS)) play a more important role in heart diseases through their signaling functions.
Correspondingly this work is dedicated to the consideration of damaging signaling by ROS and RNS in various heart and vascular disorders: heart failure (congestive heart failure or CHF), left ventricular hypertrophy (LVH), coronary heart disease, cardiac arrhythmias, and so forth.
It will be demonstrated that ROS overproduction (oxidative stress) is a main origin of the transformation of normal physiological signaling processes into the damaging ones.
Furthermore the favorable effects of low/moderate oxidative stress through preconditioning mechanisms in ischemia/reperfusion will be considered.
And in the last part we will discuss the possibility of efficient application of antioxidants and enzyme/gene inhibitors for the regulation of damaging ROS signaling in heart disorders.
American Psychological Association (APA)
Afanas'ev, Igor. 2011. ROS and RNS Signaling in Heart Disorders : Could Antioxidant Treatment Be Successful?. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-461069
Modern Language Association (MLA)
Afanas'ev, Igor. ROS and RNS Signaling in Heart Disorders : Could Antioxidant Treatment Be Successful?. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-461069
American Medical Association (AMA)
Afanas'ev, Igor. ROS and RNS Signaling in Heart Disorders : Could Antioxidant Treatment Be Successful?. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-461069
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461069