ROS and RNS Signaling in Heart Disorders : Could Antioxidant Treatment Be Successful?

Author

Afanas'ev, Igor

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-09-08

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Natural & Life Sciences (Multidisciplinary)
Biology

Abstract EN

There is not too much success in the antioxidant treatment of heart deceases in humans.

However a new approach is now developed that suggests that depending on their structures and concentrations antioxidants can exhibit much more complicated functions in many pathological disorders.

It is now well established that physiological free radicals superoxide and nitric oxide together with their derivatives hydrogen peroxide and peroxynitrite (all are named reactive oxygen species (ROS) and reactive nitrogen species (RNS)) play a more important role in heart diseases through their signaling functions.

Correspondingly this work is dedicated to the consideration of damaging signaling by ROS and RNS in various heart and vascular disorders: heart failure (congestive heart failure or CHF), left ventricular hypertrophy (LVH), coronary heart disease, cardiac arrhythmias, and so forth.

It will be demonstrated that ROS overproduction (oxidative stress) is a main origin of the transformation of normal physiological signaling processes into the damaging ones.

Furthermore the favorable effects of low/moderate oxidative stress through preconditioning mechanisms in ischemia/reperfusion will be considered.

And in the last part we will discuss the possibility of efficient application of antioxidants and enzyme/gene inhibitors for the regulation of damaging ROS signaling in heart disorders.

American Psychological Association (APA)

Afanas'ev, Igor. 2011. ROS and RNS Signaling in Heart Disorders : Could Antioxidant Treatment Be Successful?. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-461069

Modern Language Association (MLA)

Afanas'ev, Igor. ROS and RNS Signaling in Heart Disorders : Could Antioxidant Treatment Be Successful?. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-461069

American Medical Association (AMA)

Afanas'ev, Igor. ROS and RNS Signaling in Heart Disorders : Could Antioxidant Treatment Be Successful?. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-461069

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-461069