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Prevalence of Isolated Atrial Amyloidosis in Young Patients Affected by Congestive Heart Failure
Joint Authors
Ghezzi, Lorenzo
Tanganelli, Piero
Braconi, Daniela
Millucci, Lia
Santucci, Annalisa
Bernardini, Giulia
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Atrial natriuretic peptide (ANP), whose amyloid is responsible of isolated atrial amyloidosis (IAA), is known to play an important role in the pathophysiology of congestive heart failure (CHF).
We provide here the microscopic examination of atrial biopsies from 36 young (mean 40 years) CHF patients distinguished in idiopathic dilated cardiomyopathy (DC) affected and hypertrophic Cardiomyopathy (HC) affected, endorsing the presumptive association of early CHF with IAA.
We utilized a multiple method, using Congo red (CR) staining, CR fluorescence (CRF), and immunohistochemistry to assess the presence of IAA in CHF.
Immunostaining showed a moderate deposition of IAA in the atrium surrounding working myocardium with small intracellular deposits.
Our findings suggest a monitoring of young CHF cases for the development of IAA.
Our study also demonstrated how the concurrent use of immunohistochemistry, CR, and CRF may greatly enhance the detection of low-grade amyloid deposits.
American Psychological Association (APA)
Millucci, Lia& Ghezzi, Lorenzo& Bernardini, Giulia& Braconi, Daniela& Tanganelli, Piero& Santucci, Annalisa. 2012. Prevalence of Isolated Atrial Amyloidosis in Young Patients Affected by Congestive Heart Failure. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-461085
Modern Language Association (MLA)
Millucci, Lia…[et al.]. Prevalence of Isolated Atrial Amyloidosis in Young Patients Affected by Congestive Heart Failure. The Scientific World Journal No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-461085
American Medical Association (AMA)
Millucci, Lia& Ghezzi, Lorenzo& Bernardini, Giulia& Braconi, Daniela& Tanganelli, Piero& Santucci, Annalisa. Prevalence of Isolated Atrial Amyloidosis in Young Patients Affected by Congestive Heart Failure. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-461085
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461085