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Effect of Folic Acid Supplementation in Pregnancy on Preeclampsia : The Folic Acid Clinical Trial Study
Joint Authors
Champagne, Josee
Fergusson, Dean
Rennicks White, Ruth
Wen, Shi Wu
Coyle, Doug
Fraser, William
Walker, Mark C.
Smith, Graeme N.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Preeclampsia (PE) is hypertension with proteinuria that develops during pregnancy and affects at least 5% of pregnancies.
The Effect of Folic Acid Supplementation in Pregnancy on Preeclampsia: the Folic Acid Clinical Trial (FACT) aims to recruit 3,656 high risk women to evaluate a new prevention strategy for PE: supplementation of folic acid throughout pregnancy.
Pregnant women with increased risk of developing PE presenting to a trial participating center between 80/7 and 166/7 weeks of gestation are randomized in a 1 : 1 ratio to folic acid 4.0 mg or placebo after written consent is obtained.
Intent-to-treat population will be analyzed.
The FACT study was funded by the Canadian Institutes of Health Research in 2009, and regulatory approval from Health Canada was obtained in 2010.
A web-based randomization system and electronic data collection system provide the platform for participating centers to randomize their eligible participants and enter data in real time.
To date we have twenty participating Canadian centers, of which eighteen are actively recruiting, and seven participating Australian centers, of which two are actively recruiting.
Recruitment in Argentina, UK, Netherlands, Brazil, West Indies, and United States is expected to begin by the second or third quarter of 2013.
This trial is registered with NCT01355159.
American Psychological Association (APA)
Wen, Shi Wu& Champagne, Josee& Rennicks White, Ruth& Coyle, Doug& Fraser, William& Smith, Graeme N.…[et al.]. 2013. Effect of Folic Acid Supplementation in Pregnancy on Preeclampsia : The Folic Acid Clinical Trial Study. Journal of Pregnancy،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-461127
Modern Language Association (MLA)
Wen, Shi Wu…[et al.]. Effect of Folic Acid Supplementation in Pregnancy on Preeclampsia : The Folic Acid Clinical Trial Study. Journal of Pregnancy No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-461127
American Medical Association (AMA)
Wen, Shi Wu& Champagne, Josee& Rennicks White, Ruth& Coyle, Doug& Fraser, William& Smith, Graeme N.…[et al.]. Effect of Folic Acid Supplementation in Pregnancy on Preeclampsia : The Folic Acid Clinical Trial Study. Journal of Pregnancy. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-461127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461127