Interleukin-19 in Breast Cancer
Joint Authors
Chang, Ming-Shi
Yeh, Ching-Hua
Chen, Ying-Yin
Li, Chien-Feng
Hsing, Chung-Hsi
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Inflammatory cytokines within the tumor microenvironment are linked to progression in breast cancer.
Interleukin- (IL-) 19, part of the IL-10 family, contributes to a range of diseases and disorders, such as asthma, endotoxic shock, uremia, psoriasis, and rheumatoid arthritis.
IL-19 is expressed in several types of tumor cells, especially in squamous cell carcinoma of the skin, tongue, esophagus, and lung and invasive duct carcinoma of the breast.
In breast cancer, IL-19 expression is correlated with increased mitotic figures, advanced tumor stage, higher metastasis, and poor survival.
The mechanisms of IL-19 in breast cancer have recently been explored both in vitro and in vivo.
IL-19 has an autocrine effect in breast cancer cells.
It directly promotes proliferation and migration and indirectly provides a microenvironment for tumor progression, which suggests that IL-19 is a prognostic marker in breast cancer and that antagonizing IL-19 may have therapeutic potential.
American Psychological Association (APA)
Chen, Ying-Yin& Li, Chien-Feng& Yeh, Ching-Hua& Chang, Ming-Shi& Hsing, Chung-Hsi. 2013. Interleukin-19 in Breast Cancer. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-461128
Modern Language Association (MLA)
Chen, Ying-Yin…[et al.]. Interleukin-19 in Breast Cancer. Clinical and Developmental Immunology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-461128
American Medical Association (AMA)
Chen, Ying-Yin& Li, Chien-Feng& Yeh, Ching-Hua& Chang, Ming-Shi& Hsing, Chung-Hsi. Interleukin-19 in Breast Cancer. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-461128
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461128