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Enhanced HMGB1 Expression May Contribute to Th17 Cells Activation in Rheumatoid Arthritis
Joint Authors
Wang, Shengjun
Sandoghchian Shotorbani, Siamak
Xu, Yan
Chen, Jianguo
Huang, Xinxiang
Shi, Yan
Su, Zhaoliang
Liu, Yanfang
Jiao, Zhijun
Lu, Liwei
Xu, Huaxi
Zheng, Dong
Liu, Yingzhao
Tong, Jia
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Rheumatoid arthritis(RA) is a common autoimmune disease associated with Th17 cells, but what about the effect of high-mobility group box chromosomal protein 1 (HMGB1) and the relationship between Th17-associated factors and HMGB1 in RA remains unknown.
In the present study, we investigated the mRNA levels of HMGB1, RORγt, and IL-17 in peripheral blood mononuclear cells (PBMCs) from patients with rheumatoid arthritis by quantitative real-time PCR (RT-qPCR), and the concentrations of HMGB1, IL-17, and IL-23 in plasma were detected by ELISA.
And then, the effect of HMGB1 on Th17 cells differentiation was analyzed in vitro.
Our clinical studies showed that the mRNAs of HMGB1, RORγt, and IL-17 in patients were higher than that in health control (P<0.05), especially in active RA patients (P<0.05).
The plasma HMGB1, IL-17, and IL-23 in RA patients were also higher than that in health control (P<0.05); there was a positive correlation between the expression levels of HMGB1 and the amount of CRP, ERS, and RF in plasma.
In vitro, the IL-17-produced CD4+T cells were increased with 100 ng/mL rHMGB1 for 12h, which indicated that the increased HMGB1 might contribute to Th17 cells activation in RA patients.
American Psychological Association (APA)
Shi, Yan& Sandoghchian Shotorbani, Siamak& Su, Zhaoliang& Liu, Yanfang& Tong, Jia& Zheng, Dong…[et al.]. 2011. Enhanced HMGB1 Expression May Contribute to Th17 Cells Activation in Rheumatoid Arthritis. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-461200
Modern Language Association (MLA)
Shi, Yan…[et al.]. Enhanced HMGB1 Expression May Contribute to Th17 Cells Activation in Rheumatoid Arthritis. Clinical and Developmental Immunology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-461200
American Medical Association (AMA)
Shi, Yan& Sandoghchian Shotorbani, Siamak& Su, Zhaoliang& Liu, Yanfang& Tong, Jia& Zheng, Dong…[et al.]. Enhanced HMGB1 Expression May Contribute to Th17 Cells Activation in Rheumatoid Arthritis. Clinical and Developmental Immunology. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-461200
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461200