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Biological Effects of Phosphate on Fibroblast-Like Synoviocytes
Joint Authors
Hanley, Edward N.
Mauerhan, David R.
Chaturvedi, Deepthi
Gruber, Helen E.
Sun, Yubo
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This study sought to examine the expression of genes implicated in phosphate transport and pathological calcification in osteoarthritis (OA) and rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) and investigate the biological effects of phosphate.
Results revealed that several genes, which were implicated in phosphate transport and pathological calcification, were differentially expressed in OA FLS and RA FLS.
Phosphate stimulated the expression of matrix metalloproteinse-1, matrix metalloproteinse-3, cyclooxygenase-2, and interleukin-1β in a dose-dependent manner.
Phosphate also induced OA FLS cell death but not RA FLS cell death at higher concentration.
Calcification inhibitors, phosphocitrate (PC), and ethane-1-hydroxy-1,1-diphosphonate (EHDP), effectively inhibited these detrimental biological effects of phosphate.
These findings suggest that abnormal expression of genes implicated in phosphate transport and pathological calcification may contribute to the progression of OA through the induction of extracellular matrix-degrading enzymes, proinflammatory cytokines, cell death, and calcium deposits.
Calcification inhibitors such as PC and EHDP are potent inhibitors of these detrimental biological effects of phosphate.
American Psychological Association (APA)
Sun, Yubo& Mauerhan, David R.& Chaturvedi, Deepthi& Hanley, Edward N.& Gruber, Helen E.. 2012. Biological Effects of Phosphate on Fibroblast-Like Synoviocytes. ISRN Cell Biology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-461220
Modern Language Association (MLA)
Sun, Yubo…[et al.]. Biological Effects of Phosphate on Fibroblast-Like Synoviocytes. ISRN Cell Biology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-461220
American Medical Association (AMA)
Sun, Yubo& Mauerhan, David R.& Chaturvedi, Deepthi& Hanley, Edward N.& Gruber, Helen E.. Biological Effects of Phosphate on Fibroblast-Like Synoviocytes. ISRN Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-461220
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461220