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The Reactivity of 2-Ethoxy-4-Chloroquinazoline and Its Use in Synthesis of Novel Quinazoline Derivatives
Joint Authors
El-Bassiouny, F. A.
Darwish, K. M.
Rizk, S. A.
El-Hashash, M. A.
Source
Organic Chemistry International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The behavior of 2-ethoxy-4-chloroquinazoline 2 towards various nitrogen nucleophiles, namely: thiosemicarbazide, sodium azide, glucosamine, ethanol, and hydrazine hydrate has been discussed.
Also, the behavior of 4-(2-ethoxyquinazolin-4-yl)thiosemicarbazide towards one-carbon, for example, ethyl chloroformate, and two-carbon donors, for example, ethyl chloroacetate and diethyl oxalate has been investigated.
On the other hand, new 5-ethoxy-2-substituted[1,2,4]-triazolo-[1,5-c]quinazoline derivatives have been obtained by ring closure accompanied with Dimroth rearrangement through the interaction of compound 2 with hydrazides of acetic, benzoic, crotonic, cinnamic, 2-furoic, and phthalimidoacetic acids.
Structures of the novel products were confirmed by elemental, IR, MS, and 1H-NMR spectral analyses.
American Psychological Association (APA)
El-Hashash, M. A.& Darwish, K. M.& Rizk, S. A.& El-Bassiouny, F. A.. 2011. The Reactivity of 2-Ethoxy-4-Chloroquinazoline and Its Use in Synthesis of Novel Quinazoline Derivatives. Organic Chemistry International،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-461239
Modern Language Association (MLA)
El-Hashash, M. A.…[et al.]. The Reactivity of 2-Ethoxy-4-Chloroquinazoline and Its Use in Synthesis of Novel Quinazoline Derivatives. Organic Chemistry International No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-461239
American Medical Association (AMA)
El-Hashash, M. A.& Darwish, K. M.& Rizk, S. A.& El-Bassiouny, F. A.. The Reactivity of 2-Ethoxy-4-Chloroquinazoline and Its Use in Synthesis of Novel Quinazoline Derivatives. Organic Chemistry International. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-461239
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461239