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Anticonvulsant Drugs, Brain Glutamate Dehydrogenase Activity and Oxygen Consumption
Joint Authors
Ceballos Reyes, Guillermo
Vega Rasgado, Lourdes A.
Vega-Díaz, Fernando
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
Glutamate dehydrogenase (GDH, E.C.
1.4.1.3.) is a key enzyme for the biosynthesis and modulation of glutamate (GLU) metabolism and an indirect γ-aminobutyric acid (GABA) source, here we studied the effect of anticonvulsants such as pyridoxal phosphate (PPAL), aminooxyacetic acid (AAOA), and hydroxylamine (OHAMINE) on GDH activity in mouse brain.
Moreover, since GLU is a glucogenic molecule and anoxia is a primary cause of convulsions, we explore the effect of these drugs on oxygen consumption.
Experiments were performed in vitro as well as in vivo for both oxidative deamination of GLU and reductive amination of α-ketoglutarate (αK).
Results in vitro showed that PPAL decreased oxidative deamination of GLU and oxygen consumption, whereas AAOA and OHAMINE inhibited GDH activity competitively and also inhibited oxygen consumption when αK reductive amination was carried out.
In contrast, results showed that in vivo, all anticonvulsants enhanced GLU utilization by GDH and also decreased oxygen consumption.
Together, results suggest that GDH activity has repercussions on oxygen consumption, which may indicate that the enzyme activity is highly regulated by energy requirements for metabolic activity.
Besides, GDH may participate in regulation of GLU and, indirectly GABA levels, hence in neuronal excitability, becoming a key enzyme in seizures mechanism.
American Psychological Association (APA)
Vega Rasgado, Lourdes A.& Ceballos Reyes, Guillermo& Vega-Díaz, Fernando. 2012. Anticonvulsant Drugs, Brain Glutamate Dehydrogenase Activity and Oxygen Consumption. ISRN Pharmacology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-461267
Modern Language Association (MLA)
Vega Rasgado, Lourdes A.…[et al.]. Anticonvulsant Drugs, Brain Glutamate Dehydrogenase Activity and Oxygen Consumption. ISRN Pharmacology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-461267
American Medical Association (AMA)
Vega Rasgado, Lourdes A.& Ceballos Reyes, Guillermo& Vega-Díaz, Fernando. Anticonvulsant Drugs, Brain Glutamate Dehydrogenase Activity and Oxygen Consumption. ISRN Pharmacology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-461267
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461267