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Application of Mild Therapeutic Hypothermia on Stroke : A Systematic Review and Meta-Analysis
Joint Authors
Lakhan, Shaheen E.
Pamplona, Fabricio
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Stroke occurs due to an interruption in cerebral blood supply affecting neuronal function.
Body temperature on hospital admission is an important predictor of clinical outcome.
Therapeutic hypothermia is promising in clinical settings for stroke neuroprotection.
Methods.
MEDLINE/PubMed, CENTRAL, Stroke Center, and ClinicalTrials.gov were systematically searched for hypothermia intervention induced by external or endovascular cooling for acute stroke.
NIH Stroke Scale (NIHSS) and modified Rankin Scale (mRS) were the main stroke scales used, and mortality was also reported.
A meta-analysis was carried out on stroke severity and mortality.
Results.
Seven parallel-controlled clinical trials were included in the meta-analysis.
Sample sizes ranged from 18 to 62 patients, yielding a total of 288.
Target temperature (∼33°C) was reached within 3-4 hours.
Stroke severity (Cohen's d=−0.17, 95% CI: −0.42 to 0.08, P=0.32; I2 = 73%; Chi2 = 21.89, P=0.0001) and mortality (RR=1.60, 95% CI: 0.93 to 2.78, P=0.11; I2 = 0%; Chi2 = 2.88, P=0.72) were not significantly affected by hypothermia.
Discussion.
Hypothermia does not significantly improve stroke severity; however, this finding should be taken with caution due to the high heterogeneity and limited number of included studies.
No impact on mortality was observed.
American Psychological Association (APA)
Lakhan, Shaheen E.& Pamplona, Fabricio. 2012. Application of Mild Therapeutic Hypothermia on Stroke : A Systematic Review and Meta-Analysis. Stroke Research and Treatment،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-461271
Modern Language Association (MLA)
Lakhan, Shaheen E.& Pamplona, Fabricio. Application of Mild Therapeutic Hypothermia on Stroke : A Systematic Review and Meta-Analysis. Stroke Research and Treatment No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-461271
American Medical Association (AMA)
Lakhan, Shaheen E.& Pamplona, Fabricio. Application of Mild Therapeutic Hypothermia on Stroke : A Systematic Review and Meta-Analysis. Stroke Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-461271
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461271