Thrombospondin-1 : Multiple Paths to Inflammation
Joint Authors
Pidcock, Kenneth
Lopez-Dee, Zenaida
Gutierrez, Linda S.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Inflammation is a defensive process against tissue injury.
Once this self-protective strategy is initiated, an effective resolution of the process is crucial to avoid major and unnecessary tissue damage.
If the underlying event inducing inflammation is not addressed and homeostasis is not restored, this process can become chronic and lead to angiogenesis and carcinogenesis.
Thrombospondin-1 (TSP-1) is a matricellular protein involved in angiogenesis, cancer, and inflammation.
The effects of TSP-1 have been studied in many preclinical tumor models, and mimetic peptides are being tested in cancer clinical trials.
However, the molecular mechanisms explaining its role in inflammatory processes are not well understood.
This paper will discuss the role of TSP-1 in inflammation and its interaction with key receptors that may explain its functions in that process.
Recent literature will be reviewed showing novel mechanisms by which this multifaceted protein could modulate the inflammatory process and impact its resolution.
American Psychological Association (APA)
Lopez-Dee, Zenaida& Pidcock, Kenneth& Gutierrez, Linda S.. 2011. Thrombospondin-1 : Multiple Paths to Inflammation. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-461286
Modern Language Association (MLA)
Lopez-Dee, Zenaida…[et al.]. Thrombospondin-1 : Multiple Paths to Inflammation. Mediators of Inflammation No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-461286
American Medical Association (AMA)
Lopez-Dee, Zenaida& Pidcock, Kenneth& Gutierrez, Linda S.. Thrombospondin-1 : Multiple Paths to Inflammation. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-461286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461286