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The Conformation and Assignment of the Proton NMR Spectrum in Water of DX600, a Bioactive Peptide with a Random Coil Conformation
Joint Authors
Peprah, Richard B.
Carrell, Timothy N.
Steinmetz, Wayne E.
Source
International Journal of Spectroscopy
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
DX600, a small peptide with 26 residues, is a potent, highly selective inhibitor of angiotensin converting enzyme 2 (ACE2).
A range of NMR methods including TOCSY and ROESY yield an assignment of its proton spectrum in water and constraints on its conformation.
Constrained molecular dynamics simulations of solvated DX600 show that the peptide's most abundant conformer adopts a predominantly random coil conformation.
Constrained by the disulfide bond, its backbone defines an overhand knot with frayed ends.
American Psychological Association (APA)
Steinmetz, Wayne E.& Carrell, Timothy N.& Peprah, Richard B.. 2011. The Conformation and Assignment of the Proton NMR Spectrum in Water of DX600, a Bioactive Peptide with a Random Coil Conformation. International Journal of Spectroscopy،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-461306
Modern Language Association (MLA)
Steinmetz, Wayne E.…[et al.]. The Conformation and Assignment of the Proton NMR Spectrum in Water of DX600, a Bioactive Peptide with a Random Coil Conformation. International Journal of Spectroscopy No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-461306
American Medical Association (AMA)
Steinmetz, Wayne E.& Carrell, Timothy N.& Peprah, Richard B.. The Conformation and Assignment of the Proton NMR Spectrum in Water of DX600, a Bioactive Peptide with a Random Coil Conformation. International Journal of Spectroscopy. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-461306
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461306