Analysis of Insulin in Human Breast Milk in Mothers with Type 1 and Type 2 Diabetes Mellitus
Joint Authors
Hartmann, Peter E.
Trengove, N. J.
Whitmore, T. J.
Graham, D. F.
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Despite the important role that insulin plays in the human body, very little is known about its presence in human milk.
Levels rapidly decrease during the first few days of lactation and then, unlike other serum proteins of similar size, achieve comparable levels to those in serum.
Despite this, current guides for medical treatment suggest that insulin does not pass into milk, raising the question of where the insulin in milk originates.
Five mothers without diabetes, 4 mothers with type 1, and 5 mothers with type 2 diabetes collected milk samples over a 24-hour period.
Samples were analysed for total and endogenous insulin content and for c-peptide content.
All of the insulin present in the milk of type 1 mothers was artificial, and c-peptide levels were 100x lower than in serum.
This demonstrates that insulin is transported into human milk at comparable concentration to serum, suggesting an active transport mechanism.
The role of insulin in milk is yet to be determined; however, there are a number of potential implications for the infant of the presence of artificial insulins in milk.
American Psychological Association (APA)
Whitmore, T. J.& Trengove, N. J.& Graham, D. F.& Hartmann, Peter E.. 2012. Analysis of Insulin in Human Breast Milk in Mothers with Type 1 and Type 2 Diabetes Mellitus. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-461316
Modern Language Association (MLA)
Whitmore, T. J.…[et al.]. Analysis of Insulin in Human Breast Milk in Mothers with Type 1 and Type 2 Diabetes Mellitus. International Journal of Endocrinology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-461316
American Medical Association (AMA)
Whitmore, T. J.& Trengove, N. J.& Graham, D. F.& Hartmann, Peter E.. Analysis of Insulin in Human Breast Milk in Mothers with Type 1 and Type 2 Diabetes Mellitus. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-461316
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461316