Bone-Forming Capabilities of a Newly Developed NanoHA Composite Alloplast Infused with Collagen : A Pilot Study in the Sheep Mandible
Joint Authors
Granato, Rodrigo
Jimbo, Ryo
Tovar, Nick
Lorenzoni, Fabio Cesar
Gil, Jose
Coelho, Paulo G.
Teixeira, Hellen
Bonfante, Estevam A.
Marin, Charles
Witek, Lukasz
Source
International Journal of Dentistry
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Lateral or vertical bone augmentation has always been a challenge, since the site is exposed to constant pressure from the soft tissue, and blood supply only exists from the donor site.
Although, for such clinical cases, onlay grafting with autogenous bone is commonly selected, the invasiveness of the secondary surgical site and the relatively fast resorption rate have been reported as a drawback, which motivated the investigation of alternative approaches.
This study evaluated the bone-forming capability of a novel nanoHA alloplast infused with collagen graft material made from biodegradable polylactic acid/polyglycolic acid versus a control graft material with the same synthesized alloplast without the nanoHA component and collagen infiltration.
The status of newly formed bone and the resorption of the graft material were evaluated at 6 weeks in vivo histologically and three dimensionally by means of 3D microcomputed tomography.
The histologic observation showed that newly formed bone ingrowth and internal resorption of the block were observed for the experimental blocks, whereas for the control blocks less bone ingrowth occurred along with lower resorption rate of the block material.
The three-dimensional observation indicated that the experimental block maintained the external geometry, but at the same time successfully altered the graft material into bone.
It is suggested that the combination of numerous factors contributed to the bone ingrowth and the novel development could be an alternative bone grafting choice.
American Psychological Association (APA)
Marin, Charles& Jimbo, Ryo& Lorenzoni, Fabio Cesar& Witek, Lukasz& Teixeira, Hellen& Bonfante, Estevam A.…[et al.]. 2013. Bone-Forming Capabilities of a Newly Developed NanoHA Composite Alloplast Infused with Collagen : A Pilot Study in the Sheep Mandible. International Journal of Dentistry،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-461318
Modern Language Association (MLA)
Marin, Charles…[et al.]. Bone-Forming Capabilities of a Newly Developed NanoHA Composite Alloplast Infused with Collagen : A Pilot Study in the Sheep Mandible. International Journal of Dentistry No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-461318
American Medical Association (AMA)
Marin, Charles& Jimbo, Ryo& Lorenzoni, Fabio Cesar& Witek, Lukasz& Teixeira, Hellen& Bonfante, Estevam A.…[et al.]. Bone-Forming Capabilities of a Newly Developed NanoHA Composite Alloplast Infused with Collagen : A Pilot Study in the Sheep Mandible. International Journal of Dentistry. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-461318
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461318