Focal Adhesion Kinases in Adhesion Structures and Disease
Joint Authors
Eleniste, Pierre P.
Bruzzaniti, Angela
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Cell adhesion to the extracellular matrix (ECM) is essential for cell migration, proliferation, and embryonic development.
Cells can contact the ECM through a wide range of matrix contact structures such as focal adhesions, podosomes, and invadopodia.
Although they are different in structural design and basic function, they share common remodeling proteins such as integrins, talin, paxillin, and the tyrosine kinases FAK, Pyk2, and Src.
In this paper, we compare and contrast the basic organization and role of focal adhesions, podosomes, and invadopodia in different cells.
In addition, we discuss the role of the tyrosine kinases, FAK, Pyk2, and Src, which are critical for the function of the different adhesion structures.
Finally, we discuss the essential role of these tyrosine kinases from the perspective of human diseases.
American Psychological Association (APA)
Eleniste, Pierre P.& Bruzzaniti, Angela. 2012. Focal Adhesion Kinases in Adhesion Structures and Disease. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-461324
Modern Language Association (MLA)
Eleniste, Pierre P.& Bruzzaniti, Angela. Focal Adhesion Kinases in Adhesion Structures and Disease. Journal of Signal Transduction No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-461324
American Medical Association (AMA)
Eleniste, Pierre P.& Bruzzaniti, Angela. Focal Adhesion Kinases in Adhesion Structures and Disease. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-461324
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461324