Focal Adhesion Kinases in Adhesion Structures and Disease

Joint Authors

Eleniste, Pierre P.
Bruzzaniti, Angela

Source

Journal of Signal Transduction

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-07-19

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Biology

Abstract EN

Cell adhesion to the extracellular matrix (ECM) is essential for cell migration, proliferation, and embryonic development.

Cells can contact the ECM through a wide range of matrix contact structures such as focal adhesions, podosomes, and invadopodia.

Although they are different in structural design and basic function, they share common remodeling proteins such as integrins, talin, paxillin, and the tyrosine kinases FAK, Pyk2, and Src.

In this paper, we compare and contrast the basic organization and role of focal adhesions, podosomes, and invadopodia in different cells.

In addition, we discuss the role of the tyrosine kinases, FAK, Pyk2, and Src, which are critical for the function of the different adhesion structures.

Finally, we discuss the essential role of these tyrosine kinases from the perspective of human diseases.

American Psychological Association (APA)

Eleniste, Pierre P.& Bruzzaniti, Angela. 2012. Focal Adhesion Kinases in Adhesion Structures and Disease. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-461324

Modern Language Association (MLA)

Eleniste, Pierre P.& Bruzzaniti, Angela. Focal Adhesion Kinases in Adhesion Structures and Disease. Journal of Signal Transduction No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-461324

American Medical Association (AMA)

Eleniste, Pierre P.& Bruzzaniti, Angela. Focal Adhesion Kinases in Adhesion Structures and Disease. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-461324

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-461324