Genetically Engineered Islets and Alternative Sources of Insulin-Producing Cells for Treating Autoimmune Diabetes : Quo Vadis?
Joint Authors
Sytwu, Huey-Kang
Chou, Feng-Cheng
Huang, Shing-Hwa
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Islet transplantation is a promising therapy for patients with type 1 diabetes that can provide moment-to-moment metabolic control of glucose and allow them to achieve insulin independence.
However, two major problems need to be overcome: (1) detrimental immune responses, including inflammation induced by the islet isolation/transplantation procedure, recurrence autoimmunity, and allorejection, can cause graft loss and (2) inadequate numbers of organ donors.
Several gene therapy approaches and pharmaceutical treatments have been demonstrated to prolong the survival of pancreatic islet grafts in animal models; however, the clinical applications need to be investigated further.
In addition, for an alternative source of pancreatic β-cell replacement therapy, the ex vivo generation of insulin-secreting cells from diverse origins of stem/progenitor cells has become an attractive option in regenerative medicine.
This paper focuses on the genetic manipulation of islets during transplantation therapy and summarizes current strategies to obtain functional insulin-secreting cells from stem/progenitor cells.
American Psychological Association (APA)
Chou, Feng-Cheng& Huang, Shing-Hwa& Sytwu, Huey-Kang. 2012. Genetically Engineered Islets and Alternative Sources of Insulin-Producing Cells for Treating Autoimmune Diabetes : Quo Vadis?. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-461333
Modern Language Association (MLA)
Chou, Feng-Cheng…[et al.]. Genetically Engineered Islets and Alternative Sources of Insulin-Producing Cells for Treating Autoimmune Diabetes : Quo Vadis?. International Journal of Endocrinology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-461333
American Medical Association (AMA)
Chou, Feng-Cheng& Huang, Shing-Hwa& Sytwu, Huey-Kang. Genetically Engineered Islets and Alternative Sources of Insulin-Producing Cells for Treating Autoimmune Diabetes : Quo Vadis?. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-461333
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461333