The Effect of Antihelminthic Treatment on Subjects with Asthma from an Endemic Area of Schistosomiasis : A Randomized, Double-Blinded, and Placebo-Controlled Trial
Joint Authors
De Souza, Robson Da Paixão
Almeida, Maria Cecília F.
Campos, Régis A.
Lima, Givaneide S.
Cardoso, Luciana Santos
Cruz, Alvaro A.
Figueiredo, Joanemile P.
Ilma Araujo, Maria
Carvalho, Edgar M.
Oliveira, Ricardo Riccio
Source
Journal of Parasitology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This is a prospective, double-blinded, and placebo-controlled trial evaluating the influence of antihelminthic treatments on asthma severity in individuals living in an endemic area of schistosomiasis.
Patients from group 1 received placebo of Albendazole or of Praziquantel and from group 2 received Albendazole and Praziquantel.
Asthma severity was assessed by clinical scores and by pulmonary function test.
There was no significant difference in the asthma scores from D0 to D1–D7 after Albendazole or Praziquantel and from D0 to D30–90 after Albendazole or Praziquantel in both, group 1 and 2.
It was observed, however, a clinical worsening of the overall studied population after 6 months and 12 months of antihelminthic treatments.
Additionally, we observed increased frequency of forced expiratory volume in 1 second (FEV1) <80% on 12 and 18 months after treatment.
The worsening of asthma severity after repeated antihelminthic treatments is consistent with the hypothesis of the protective role conferred by helminths in atopic diseases.
American Psychological Association (APA)
Almeida, Maria Cecília F.& Lima, Givaneide S.& Cardoso, Luciana Santos& De Souza, Robson Da Paixão& Campos, Régis A.& Cruz, Alvaro A.…[et al.]. 2012. The Effect of Antihelminthic Treatment on Subjects with Asthma from an Endemic Area of Schistosomiasis : A Randomized, Double-Blinded, and Placebo-Controlled Trial. Journal of Parasitology Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-461356
Modern Language Association (MLA)
Almeida, Maria Cecília F.…[et al.]. The Effect of Antihelminthic Treatment on Subjects with Asthma from an Endemic Area of Schistosomiasis : A Randomized, Double-Blinded, and Placebo-Controlled Trial. Journal of Parasitology Research No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-461356
American Medical Association (AMA)
Almeida, Maria Cecília F.& Lima, Givaneide S.& Cardoso, Luciana Santos& De Souza, Robson Da Paixão& Campos, Régis A.& Cruz, Alvaro A.…[et al.]. The Effect of Antihelminthic Treatment on Subjects with Asthma from an Endemic Area of Schistosomiasis : A Randomized, Double-Blinded, and Placebo-Controlled Trial. Journal of Parasitology Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-461356
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461356