Naltrexone Reverses Ethanol-Induced Rat Hippocampal and Serum Oxidative Damage
Joint Authors
Romero, Francisco Javier
Muriach, María
Barcia, Jorge M.
Miranda, María
Almansa, Inmaculada
López-Pedrajas, Rosa
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Naltrexone, an antagonist of μ-opioid receptors, is clinically used as adjuvant therapy of alcohol dishabituation.
The aim of the present work was to test the effect of 1 mg/kg body weight of naltrexone to revert oxidative stress-related biochemical alterations, in the hippocampus and serum of chronic alcoholic adult rats.
Malondialdehyde concentration was increased and glutathione peroxidase activity was decreased in hippocampus and serum of alcohol-treated rats.
Naltrexone treatment restored these alterations.
The in vitro antioxidant ability of Ntx could not justify these effects considering the doses used.
Thus this apparent protective effect of Ntx can only be attributed to its pharmacological effects, as herein discussed.
American Psychological Association (APA)
Almansa, Inmaculada& Barcia, Jorge M.& López-Pedrajas, Rosa& Muriach, María& Miranda, María& Romero, Francisco Javier. 2013. Naltrexone Reverses Ethanol-Induced Rat Hippocampal and Serum Oxidative Damage. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-461361
Modern Language Association (MLA)
Almansa, Inmaculada…[et al.]. Naltrexone Reverses Ethanol-Induced Rat Hippocampal and Serum Oxidative Damage. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-461361
American Medical Association (AMA)
Almansa, Inmaculada& Barcia, Jorge M.& López-Pedrajas, Rosa& Muriach, María& Miranda, María& Romero, Francisco Javier. Naltrexone Reverses Ethanol-Induced Rat Hippocampal and Serum Oxidative Damage. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-461361
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461361