![](/images/graphics-bg.png)
The Effect of Neonatal Leptin Antagonism in Male Rat Offspring Is Dependent upon the Interaction between Prior Maternal Nutritional Status and Post-Weaning Diet
Joint Authors
Truong, M.
Vickers, Mark H.
Connor, K. L.
Sloboda, Deborah M.
Beltrand, J.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Epidemiological and experimental studies report associations between overweight mothers and increased obesity risk in offspring.
It is unclear whether neonatal leptin regulation mediates this association between overweight mothers and offspring obesity.
We investigated the effect of neonatal treatment with a leptin antagonist (LA) on growth and metabolism in offspring of mothers fed either a control or a high fat diet.
Wistar rats were fed either a control (CON) or a high fat diet (MHF) during pregnancy and lactation.
Male CON and MHF neonates received either saline (S) or a rat-specific pegylated LA on days 3, 5, and 7.
Offspring were weaned onto either a control or a high fat (hf) diet.
At day 100, body composition, blood glucose, β-hydroxybutyrate and plasma leptin and insulin were determined.
In CON and MHF offspring, LA increased neonatal bodyweights compared to saline-treated offspring and was more pronounced in MHF offspring.
In the post-weaning period, neonatal LA treatment decreased hf diet-induced weight gain but only in CON offspring.
LA treatment induced changes in body length, fat mass, body temperature, and bone composition.
Neonatal LA treatment can therefore exert effects on growth and metabolism in adulthood but is dependent upon interactions between maternal and post-weaning nutrition.
American Psychological Association (APA)
Beltrand, J.& Sloboda, Deborah M.& Connor, K. L.& Truong, M.& Vickers, Mark H.. 2012. The Effect of Neonatal Leptin Antagonism in Male Rat Offspring Is Dependent upon the Interaction between Prior Maternal Nutritional Status and Post-Weaning Diet. Journal of Nutrition and Metabolism،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-461366
Modern Language Association (MLA)
Beltrand, J.…[et al.]. The Effect of Neonatal Leptin Antagonism in Male Rat Offspring Is Dependent upon the Interaction between Prior Maternal Nutritional Status and Post-Weaning Diet. Journal of Nutrition and Metabolism No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-461366
American Medical Association (AMA)
Beltrand, J.& Sloboda, Deborah M.& Connor, K. L.& Truong, M.& Vickers, Mark H.. The Effect of Neonatal Leptin Antagonism in Male Rat Offspring Is Dependent upon the Interaction between Prior Maternal Nutritional Status and Post-Weaning Diet. Journal of Nutrition and Metabolism. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-461366
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461366