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Mycobacterium tuberculosis P-Type ATPases : Possible Targets for Drug or Vaccine Development
Joint Authors
Soto Ospina, Carlos Yesid
Novoa-Aponte, Lorena
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Tuberculosis (TB) has been the biggest killer in the human history; currently, Mycobacterium tuberculosis (Mtb) kills nearly 2 million people each year worldwide.
The high prevalence of TB obligates the identification of new therapeutic targets and the development of anti-TB vaccines that can control multidrug resistance and latent TB infections.
Membrane proteins have recently been suggested as key targets for bacterial viability.
Current studies have shown that mycobacteria P-type ATPases may play critical roles in ion homeostasis and in the response of mycobacteria to toxic substances in the intraphagosomal environment.
In this review, we bring together the genomic, transcriptomic, and structural aspects of the P-type ATPases that are relevant during active and latent Mtb infections, which can be useful in determining the potential of these ATPases as drug targets and in uncovering their possible roles in the development of new anti-TB attenuated vaccines.
American Psychological Association (APA)
Novoa-Aponte, Lorena& Soto Ospina, Carlos Yesid. 2014. Mycobacterium tuberculosis P-Type ATPases : Possible Targets for Drug or Vaccine Development. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-461372
Modern Language Association (MLA)
Novoa-Aponte, Lorena& Soto Ospina, Carlos Yesid. Mycobacterium tuberculosis P-Type ATPases : Possible Targets for Drug or Vaccine Development. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-461372
American Medical Association (AMA)
Novoa-Aponte, Lorena& Soto Ospina, Carlos Yesid. Mycobacterium tuberculosis P-Type ATPases : Possible Targets for Drug or Vaccine Development. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-461372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461372