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Antiadhesive Property of Photoreactive Azidophenyl Low-Molecular-Weight Chitosan in Rabbit Laminotomy Model
Joint Authors
Kim, Mi Kyung
Son, Tae Il
Kim, Jong Won
Kang, Hyun
Jang, Eui-Chan
Song, Kwang-Sup
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Newly developed photoreactive azidophenyl chitosan (P-ALMC) has characteristics of a transformable gel type and its outer layer could be sealed up like a film after UV radiation.
We aim to evaluate the antiadhesive properties of P-ALMC through comparing it with hyaluronic acid-carboxymethylcellulose membrane (HA-CMC) in a rabbit laminotomy model.
Laminotomies were performed at the L3-4, L4-5, and L5-6 levels in 41 rabbits and each level was randomly assigned to either receive saline (group I), HA-CMC (group II), or P-ALMC (group III).
The extent of peridural fibrosis, density of fibroblasts and inflammatory cells, and dural thickness were evaluated at 6 and 12 weeks postoperatively.
In the groups II and III, the extents of peridural fibrosis and dural thickness were significantly smaller than those in group I (P<0.001) and no differences between groups II and III were found at the postoperative 6 and 12 weeks.
There were no differences of cell density among groups.
P-ALMC showed effective antiadhesive properties comparable to HA-CMC and could be one of the candidates as an anti-adhesive agent for spine surgery even further study is required to identify the effectiveness of its unique characteristics as mechanical barrier.
American Psychological Association (APA)
Kim, Jong Won& Song, Kwang-Sup& Kang, Hyun& Jang, Eui-Chan& Kim, Mi Kyung& Son, Tae Il. 2013. Antiadhesive Property of Photoreactive Azidophenyl Low-Molecular-Weight Chitosan in Rabbit Laminotomy Model. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-461393
Modern Language Association (MLA)
Kim, Jong Won…[et al.]. Antiadhesive Property of Photoreactive Azidophenyl Low-Molecular-Weight Chitosan in Rabbit Laminotomy Model. Journal of Chemistry No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-461393
American Medical Association (AMA)
Kim, Jong Won& Song, Kwang-Sup& Kang, Hyun& Jang, Eui-Chan& Kim, Mi Kyung& Son, Tae Il. Antiadhesive Property of Photoreactive Azidophenyl Low-Molecular-Weight Chitosan in Rabbit Laminotomy Model. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-461393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461393