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Therapeutically Targeting Neuroinflammation and Microglia after Acute Ischemic Stroke
Joint Authors
Chang, Kyu-Tae
Lee, Sang-Rae
Yeo, Hyeon-Gu
Choi, Sung S.
Lee, Youngjeon
Lee, Hong Jun
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Inflammation has a pivotal role in the pathogenesis of ischemic stroke, and recent studies posit that inflammation acts as a double-edged sword, not only detrimentally augmenting secondary injury, but also potentially promoting recovery.
An initial event of inflammation in ischemic stroke is the activation of microglia, leading to production of both pro- and anti-inflammatory mediators acting through multiple receptor signaling pathways.
In this review, we discuss the role of microglial mediators in acute ischemic stroke and elaborate on preclinical and clinical studies focused on microglia in stroke models.
Understanding how microglia can lead to both pro- and anti-inflammatory responses may be essential to implement therapeutic strategies using immunomodulatory interventions in ischemic stroke.
American Psychological Association (APA)
Lee, Youngjeon& Lee, Sang-Rae& Choi, Sung S.& Yeo, Hyeon-Gu& Chang, Kyu-Tae& Lee, Hong Jun. 2014. Therapeutically Targeting Neuroinflammation and Microglia after Acute Ischemic Stroke. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-461401
Modern Language Association (MLA)
Lee, Youngjeon…[et al.]. Therapeutically Targeting Neuroinflammation and Microglia after Acute Ischemic Stroke. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-461401
American Medical Association (AMA)
Lee, Youngjeon& Lee, Sang-Rae& Choi, Sung S.& Yeo, Hyeon-Gu& Chang, Kyu-Tae& Lee, Hong Jun. Therapeutically Targeting Neuroinflammation and Microglia after Acute Ischemic Stroke. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-461401
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461401