Priapism in Sickle Cell Anemia : Emerging Mechanistic Understanding and Better Preventative Strategies
Joint Authors
Bennett, Nelson E.
Crane, Genevieve M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Sickle cell anemia is a common and disabling disorder profoundly affecting mortality as well as quality of life.
Up to 35% of men with sickle cell disease are affected by painful, prolonged erections termed ischemic priapism.
A priapic episode may result in fibrosis and permanent erectile dysfunction.
The severity of sickle cell disease manifestations is variable dependent on a number of contributing genetic factors; however, priapism tends to cluster with other severe vascular complications including pulmonary hypertension, leg ulceration, and overall risk of death.
The mechanisms underlying priapism in sickle cell disease have begun to be elucidated including hemolysis-mediated dysregulation of the nitric oxide signaling pathway and dysregulation of adenosine-mediated vasodilation.
A better understanding of these mechanisms is leading toward novel preventative strategies.
This paper will focus on the mechanisms underlying development of ischemic priapism in sickle cell disease, current acute and preventative treatment strategies, and future directions for improved management of this disorder.
American Psychological Association (APA)
Crane, Genevieve M.& Bennett, Nelson E.. 2010. Priapism in Sickle Cell Anemia : Emerging Mechanistic Understanding and Better Preventative Strategies. Anemia،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-461416
Modern Language Association (MLA)
Crane, Genevieve M.& Bennett, Nelson E.. Priapism in Sickle Cell Anemia : Emerging Mechanistic Understanding and Better Preventative Strategies. Anemia No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-461416
American Medical Association (AMA)
Crane, Genevieve M.& Bennett, Nelson E.. Priapism in Sickle Cell Anemia : Emerging Mechanistic Understanding and Better Preventative Strategies. Anemia. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-461416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461416