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Triggers and Effectors of Oxidative Stress at Blood-Brain Barrier Level : Relevance for Brain Ageing and Neurodegeneration
Joint Authors
Gherghiceanu, Mihaela
Popescu, Bogdan Ovidiu
Enciu, Ana-Maria
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
As fundamental research advances, it is becoming increasingly clear that a clinically expressed disease implies a mixture of intertwining molecular disturbances.
Oxidative stress is one of such pathogenic pathways involved in virtually all central nervous system pathologies, infectious, inflammatory, or degenerative in nature.
Since brain homeostasis largely depends on integrity of blood-brain barrier (BBB), many studies focused lately on BBB alteration in a wide spectrum of brain diseases.
The proper two-way molecular transfer through BBB depends on several factors, including the functional status of its tight junction (TJ) complexes of proteins sealing neighbour endothelial cells.
Although there is abundant experimental work showing that oxidative stress associates BBB permeability alteration, less is known about its implications, at molecular level, in TJ protein expression or TJ-related cell signalling.
In this paper, oxidative stress is presented as a common pathway for different brain pathogenic mechanisms which lead to BBB dysregulation.
We revise here oxidative-induced molecular mechanisms of BBB disruption and TJ protein expression alteration, in relation to ageing and neurodegeneration.
American Psychological Association (APA)
Enciu, Ana-Maria& Gherghiceanu, Mihaela& Popescu, Bogdan Ovidiu. 2013. Triggers and Effectors of Oxidative Stress at Blood-Brain Barrier Level : Relevance for Brain Ageing and Neurodegeneration. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-461427
Modern Language Association (MLA)
Enciu, Ana-Maria…[et al.]. Triggers and Effectors of Oxidative Stress at Blood-Brain Barrier Level : Relevance for Brain Ageing and Neurodegeneration. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-461427
American Medical Association (AMA)
Enciu, Ana-Maria& Gherghiceanu, Mihaela& Popescu, Bogdan Ovidiu. Triggers and Effectors of Oxidative Stress at Blood-Brain Barrier Level : Relevance for Brain Ageing and Neurodegeneration. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-461427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461427