Persistence of Hepatitis C RNA in Liver Allografts Is Associated with Histologic Progression Independent of Serologic Viral Clearance
Joint Authors
Dickson, R. C.
Keaveny, A.
Krishna, M.
Ghabril, M.
Satyanarayana, Raj
Lloyd, R.
Aranda-Michel, Jaime
Bonatti, H.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-05-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Hepatitis C virus (HCV) nondetectability in the liver may predict a sustained viral response (SVR) in patients with an end of treatment response.
HCV RNA can be detected in liver tissue by in situ hybridization (ISH).
Aim.
To determine if HCV nondetectability in liver allografts by ISH can predict SVR in patients who cleared virus serologically on treatment.
Methods.
Twenty five patients with undetectable serum HCV on Interferon/Ribavirin therapy for HCV recurrence post liver transplant (LT) were studied.
All had biopsies at 4 months post LT (baseline) and follow up with HCV ISH analysis performed.
Results.
10 were ISH positive (group 1); 15 were ISH negative (group 2).
Groups 1 and 2 had similar patient, donor, and viral characteristics at LT, as well as treatment duration at the time of the ISH assayed liver biopsy (13±16 versus 10±4 months P = .24).
However, group 1 had longer total treatment duration (24±10 versus 14±5 months, P = .001).
Eight (80%) group 1 and 9 (60%) group 2 patients achieved SVR.
Mean grade and stage (modified Ishak score) were similar at 4 months, however, group 1 had higher grade (3±1.7 versus 1.6±1.3, P = .039) and stage (1.4±1.4 versus 0.5±0.6, P = .084) on the ISH assayed biopsy, after similar post LT intervals (23±10 versus 24±12 months, P = .91).
Conclusion.
Allograft HCV ISH nondetectability does not predict SVR in treatment responsive HCV recurrence, but is associated with less severe histologic disease.
American Psychological Association (APA)
Ghabril, M.& Dickson, R. C.& Krishna, M.& Lloyd, R.& Aranda-Michel, Jaime& Keaveny, A.…[et al.]. 2009. Persistence of Hepatitis C RNA in Liver Allografts Is Associated with Histologic Progression Independent of Serologic Viral Clearance. Journal of Transplantation،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-461429
Modern Language Association (MLA)
Ghabril, M.…[et al.]. Persistence of Hepatitis C RNA in Liver Allografts Is Associated with Histologic Progression Independent of Serologic Viral Clearance. Journal of Transplantation No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-461429
American Medical Association (AMA)
Ghabril, M.& Dickson, R. C.& Krishna, M.& Lloyd, R.& Aranda-Michel, Jaime& Keaveny, A.…[et al.]. Persistence of Hepatitis C RNA in Liver Allografts Is Associated with Histologic Progression Independent of Serologic Viral Clearance. Journal of Transplantation. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-461429
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461429