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Modulation of Vascular Cell Function by Bim Expression
Joint Authors
Morrison, Margaret E.
Jamali, Nasim
Sorenson, Christine M.
Palenski, Tammy L.
Sheibani, Nader
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-31
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Apoptosis of vascular cells, including pericytes and endothelial cells, contributes to disease pathogenesis in which vascular rarefaction plays a central role.
Bim is a proapoptotic protein that modulates not only apoptosis but also cellular functions such as migration and extracellular matrix (ECM) protein expression.
Endothelial cells and pericytes each make a unique contribution to vascular formation and function although the details require further delineation.
Here we set out to determine the cell autonomous impact of Bim expression on retinal endothelial cell and pericyte function using cells prepared from Bim deficient (Bim−/−) mice.
Bim−/− endothelial cells displayed an increased production of ECM proteins, proliferation, migration, adhesion, and VEGF expression but, a decreased eNOS expression and nitric oxide production.
In contrast, pericyte proliferation decreased in the absence of Bim while migration, adhesion, and VEGF expression were increased.
In addition, we demonstrated that the coculturing of either wild-type or Bim−/− endothelial cells with Bim−/− pericytes diminished their capillary morphogenesis.
Thus, our data further emphasizes the importance of vascular cell autonomous regulatory mechanisms in modulation of vascular function.
American Psychological Association (APA)
Morrison, Margaret E.& Palenski, Tammy L.& Jamali, Nasim& Sheibani, Nader& Sorenson, Christine M.. 2013. Modulation of Vascular Cell Function by Bim Expression. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-461431
Modern Language Association (MLA)
Morrison, Margaret E.…[et al.]. Modulation of Vascular Cell Function by Bim Expression. International Journal of Cell Biology No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-461431
American Medical Association (AMA)
Morrison, Margaret E.& Palenski, Tammy L.& Jamali, Nasim& Sheibani, Nader& Sorenson, Christine M.. Modulation of Vascular Cell Function by Bim Expression. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-461431
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461431