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Interleukin-23 and Th17 Cells in the Control of Gut Inflammation
Joint Authors
Pallone, Francesco
Monteleone, Ivan
Monteleone, Giovanni
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-05-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Crohn's Disease and Ulcerative Colitis, the major forms of inflammatory bowel diseases (IBDs) in humans, have been traditionally associated with exaggerated and poorly controlled T helper (Th) type 1 or Th2 cell response, respectively.
More recent studies have, however, shown that IBDs are also characterized by a sustained production of cytokines made by a distinct lineage of Th cells, termed Th17 cells.
The demonstration that Th17-related cytokines cause pathology in many organs, including the gut, and that expansion and maintenance of Th17 cell responses require the activity of IL-23, a cytokine made in excess in the gut of IBD patients has contributed to elucidate new pathways of intestinal tissue damage as well as to design new therapeutic strategies.
In this review, we discuss the available data supporting the role of the IL-23/Th17 axis in the modulation of intestinal tissue inflammation.
American Psychological Association (APA)
Monteleone, Ivan& Pallone, Francesco& Monteleone, Giovanni. 2009. Interleukin-23 and Th17 Cells in the Control of Gut Inflammation. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-461441
Modern Language Association (MLA)
Monteleone, Ivan…[et al.]. Interleukin-23 and Th17 Cells in the Control of Gut Inflammation. Mediators of Inflammation No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-461441
American Medical Association (AMA)
Monteleone, Ivan& Pallone, Francesco& Monteleone, Giovanni. Interleukin-23 and Th17 Cells in the Control of Gut Inflammation. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-461441
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461441