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Germline Mutations and Polymorphisms in the Origins of Cancers in Women
Joint Authors
Hirshfield, Kim M.
Rebbeck, Timothy R.
Levine, Arnold J.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-01-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Several female malignancies including breast, ovarian, and endometrial cancers can be characterized based on known somatic and germline mutations.
Initiation and propagation of tumors reflect underlying genomic alterations such as mutations, polymorphisms, and copy number variations found in genes of multiple cellular pathways.
The contributions of any single genetic variation or mutation in a population depend on its frequency and penetrance as well as tissue-specific functionality.
Genome wide association studies, fluorescence in situ hybridization, comparative genomic hybridization, and candidate gene studies have enumerated genetic contributors to cancers in women.
These include p53, BRCA1, BRCA2, STK11, PTEN, CHEK2, ATM, BRIP1, PALB2, FGFR2, TGFB1, MDM2, MDM4 as well as several other chromosomal loci.
Based on the heterogeneity within a specific tumor type, a combination of genomic alterations defines the cancer subtype, biologic behavior, and in some cases, response to therapeutics.
Consideration of tumor heterogeneity is therefore important in the critical analysis of gene associations in cancer.
American Psychological Association (APA)
Hirshfield, Kim M.& Rebbeck, Timothy R.& Levine, Arnold J.. 2010. Germline Mutations and Polymorphisms in the Origins of Cancers in Women. Journal of Oncology،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-461445
Modern Language Association (MLA)
Hirshfield, Kim M.…[et al.]. Germline Mutations and Polymorphisms in the Origins of Cancers in Women. Journal of Oncology No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-461445
American Medical Association (AMA)
Hirshfield, Kim M.& Rebbeck, Timothy R.& Levine, Arnold J.. Germline Mutations and Polymorphisms in the Origins of Cancers in Women. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-461445
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461445