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Itk : The Rheostat of the T Cell Response
Joint Authors
Tsoukas, Constantine D.
Grasis, Juris A.
Source
Journal of Signal Transduction
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-07
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
The nonreceptor tyrosine kinase Itk plays a key role in TCR-initiated signaling that directly and significantly affects the regulation of PLCγ1 and the consequent mobilization of Ca2+.
Itk also participates in the regulation of cytoskeletal reorganization as well as cellular adhesion, which is necessary for a productive T cell response.
The functional cellular outcome of these molecular regulations by Itk renders it an important mediator of T cell development and differentiation.
This paper encompasses the structure of Itk, the signaling parameters leading to Itk activation, and Itk effects on molecular pathways resulting in functional cellular outcomes.
The incorporation of these factors persuades one to believe that Itk serves as a modulator, or rheostat, critically fine-tuning the T cell response.
American Psychological Association (APA)
Grasis, Juris A.& Tsoukas, Constantine D.. 2011. Itk : The Rheostat of the T Cell Response. Journal of Signal Transduction،Vol. 2011, no. 2011, pp.1-23.
https://search.emarefa.net/detail/BIM-461454
Modern Language Association (MLA)
Grasis, Juris A.& Tsoukas, Constantine D.. Itk : The Rheostat of the T Cell Response. Journal of Signal Transduction No. 2011 (2011), pp.1-23.
https://search.emarefa.net/detail/BIM-461454
American Medical Association (AMA)
Grasis, Juris A.& Tsoukas, Constantine D.. Itk : The Rheostat of the T Cell Response. Journal of Signal Transduction. 2011. Vol. 2011, no. 2011, pp.1-23.
https://search.emarefa.net/detail/BIM-461454
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461454