Suppressive Effect of Hydroquinone, a Benzene Metabolite, on In Vitro Inflammatory Responses Mediated by Macrophages, Monocytes, and Lymphocytes
Author
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-01-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We investigated the inhibitory effects of hydroquinone on cytokine release, phagocytosis, NO production, ROS generation, cell-cell/cell fibronectin adhesion, and lymphocyte proliferation.
We found that hydroquinone suppressed the production of proinflammatory cytokines [tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6], secretion of toxic molecules [nitric oxide (NO) and reactive oxygen species (ROS)], phagocytic uptake of FITC-labeled dextran, upregulation of costimulatory molecules, U937 cell-cell adhesion induced by CD18 and CD29, and the proliferation of lymphocytes from the bone marrow and spleen.
Considering that (1) environmental chemical stressors reduce the immune response of chronic cigarette smokers and children against bacterial and viral infections and that (2) workers in petroleum factories are at higher risk for cancer, our data suggest that hydroquinone might pathologically inhibit inflammatory responses mediated by monocytes, macrophages, and lymphocytes.
American Psychological Association (APA)
Cho, Jae Youl. 2009. Suppressive Effect of Hydroquinone, a Benzene Metabolite, on In Vitro Inflammatory Responses Mediated by Macrophages, Monocytes, and Lymphocytes. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-461466
Modern Language Association (MLA)
Cho, Jae Youl. Suppressive Effect of Hydroquinone, a Benzene Metabolite, on In Vitro Inflammatory Responses Mediated by Macrophages, Monocytes, and Lymphocytes. Mediators of Inflammation No. 2008 (2008), pp.1-11.
https://search.emarefa.net/detail/BIM-461466
American Medical Association (AMA)
Cho, Jae Youl. Suppressive Effect of Hydroquinone, a Benzene Metabolite, on In Vitro Inflammatory Responses Mediated by Macrophages, Monocytes, and Lymphocytes. Mediators of Inflammation. 2009. Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-461466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461466