Evaluation of the Association of Plasma Pentraxin 3 Levels with Type 2 Diabetes and Diabetic Nephropathy in a Malay Population
Joint Authors
Brismar, Kerstin
Abu Seman, Norhashimah
Witasp, Anna
Gu, Harvest F.
Anderstam, Björn
Stenvinkel, Peter
Wan Mohamud, Wan Nazaimoon
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Recent reports have demonstrated that elevated plasma long pentraxin 3 (PTX3) levels are associated with cardiovascular and chronic kidney diseases.
In the current study, we investigated the plasma PTX3 levels in 296 Malay subjects including the subjects with normal glucose tolerance (NGT) and type 2 diabetes (T2DM) patients with or without DN by using an enzyme-linked immune-sorbent assay.
Results showed that in males, plasma PTX3 levels in T2DM patients without DN were lower than that in the subjects with NGT (2.78 versus 3.98 ng/mL; P=0.021).
Plasma PTX3 levels in T2DM patients with DN were decreased compared to the patients without DN (1.63 versus 2.78 ng/mL; P=0.013).
In females, however, no significant alteration of plasma PTX3 levels among NGT subjects and T2DM patients with and without DN was detected.
Furthermore, an inverse correlation between PTX3 and body mass index was found in male subjects with NGT (P=0.012; r=-0.390), but not in male T2DM patients, neither in all females.
The current study provided the first evidence that decreased plasma PTX3 levels are associated with T2DM and DN in Malay men and also suggested that PTX3 may have different effects in DN and chronic kidney diseases.
American Psychological Association (APA)
Abu Seman, Norhashimah& Witasp, Anna& Wan Mohamud, Wan Nazaimoon& Anderstam, Björn& Brismar, Kerstin& Stenvinkel, Peter…[et al.]. 2013. Evaluation of the Association of Plasma Pentraxin 3 Levels with Type 2 Diabetes and Diabetic Nephropathy in a Malay Population. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-461468
Modern Language Association (MLA)
Abu Seman, Norhashimah…[et al.]. Evaluation of the Association of Plasma Pentraxin 3 Levels with Type 2 Diabetes and Diabetic Nephropathy in a Malay Population. Journal of Diabetes Research No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-461468
American Medical Association (AMA)
Abu Seman, Norhashimah& Witasp, Anna& Wan Mohamud, Wan Nazaimoon& Anderstam, Björn& Brismar, Kerstin& Stenvinkel, Peter…[et al.]. Evaluation of the Association of Plasma Pentraxin 3 Levels with Type 2 Diabetes and Diabetic Nephropathy in a Malay Population. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-461468
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461468