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Evolution of the FGF Gene Family
Joint Authors
Bertrand, Stephanie
Escriva, Hector
Oulion, Silvan
Source
International Journal of Evolutionary Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Fibroblast Growth Factors (FGFs) are small proteins generally secreted, acting through binding to transmembrane tyrosine kinase receptors (FGFRs).
Activation of FGFRs triggers several cytoplasmic cascades leading to the modification of cell behavior.
FGFs play critical roles in a variety of developmental and physiological processes.
Since their discovery in mammals, FGFs have been found in many metazoans and some arthropod viruses.
Efforts have been previously made to decipher the evolutionary history of this family but conclusions were limited due to a poor taxonomic coverage.
We took advantage of the availability of many new sequences from diverse metazoan lineages to further explore the possible evolutionary scenarios explaining the diversity of the FGF gene family.
Our analyses, based on phylogenetics and synteny conservation approaches, allow us to propose a new classification of FGF genes into eight subfamilies, and to draw hypotheses for the evolutionary events leading to the present diversity of this gene family.Erratum to “Evolution of the FGF Gene Family”dx.doi.org/10.1155/2012/789125
American Psychological Association (APA)
Oulion, Silvan& Bertrand, Stephanie& Escriva, Hector. 2012. Evolution of the FGF Gene Family. International Journal of Evolutionary Biology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-461485
Modern Language Association (MLA)
Oulion, Silvan…[et al.]. Evolution of the FGF Gene Family. International Journal of Evolutionary Biology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-461485
American Medical Association (AMA)
Oulion, Silvan& Bertrand, Stephanie& Escriva, Hector. Evolution of the FGF Gene Family. International Journal of Evolutionary Biology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-461485
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461485