Sexual Dimorphism in Hematocrit Response Following Red Blood Cell Transfusion of Critically Ill Surgical Patients
Joint Authors
Burlew, Clay C.
Silliman, Christopher C.
Moore, Ernest E.
Pieracci, Fredric M.
Johnson, Jeffery
Townsend, Nicole
Bensard, Denis D.
Biffl, Walter
Gerber, Andrew
Barnett, Carlton C.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The change in hematocrit (ΔHct) following packed red blood cell (pRBCs) transfusion is a clinically relevant measurement of transfusion efficacy that is influenced by post-transfusion hemolysis.
Sexual dimorphism has been observed in critical illness and may be related to gender-specific differences in immune response.
We investigated the relationship between both donor and recipient gender and ΔHct in an analysis of all pRBCs transfusions in our surgical intensive care unit (2006–2009).
The relationship between both donor and recipient gender and ΔHct (% points) was assessed using both univariate and multivariable analysis.
A total of 575 units of pRBCs were given to 342 patients; 289 (49.9%) donors were male.
By univariate analysis, ΔHct was significantly greater for female as compared to male recipients (3.81% versus 2.82%, resp., P<0.01).
No association was observed between donor gender and ΔHct, which was 3.02% following receipt of female blood versus 3.23% following receipt of male blood (P=0.21).
By multivariable analysis, recipient gender remained associated significantly with ΔHct (P<0.01).
In conclusion, recipient gender is independently associated with ΔHct following pRBCs transfusion.
This association does not appear related to either demographic or anthropomorphic factors, raising the possibility of gender-related differences in recipient immune response to transfusion.
American Psychological Association (APA)
Pieracci, Fredric M.& Barnett, Carlton C.& Townsend, Nicole& Moore, Ernest E.& Johnson, Jeffery& Biffl, Walter…[et al.]. 2012. Sexual Dimorphism in Hematocrit Response Following Red Blood Cell Transfusion of Critically Ill Surgical Patients. ISRN Hematology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-461501
Modern Language Association (MLA)
Pieracci, Fredric M.…[et al.]. Sexual Dimorphism in Hematocrit Response Following Red Blood Cell Transfusion of Critically Ill Surgical Patients. ISRN Hematology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-461501
American Medical Association (AMA)
Pieracci, Fredric M.& Barnett, Carlton C.& Townsend, Nicole& Moore, Ernest E.& Johnson, Jeffery& Biffl, Walter…[et al.]. Sexual Dimorphism in Hematocrit Response Following Red Blood Cell Transfusion of Critically Ill Surgical Patients. ISRN Hematology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-461501
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461501