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Correlation of DNA Ploidy with Progression of Cervical Cancer
Joint Authors
Mehrotra, S.
Singh, Madhulika
Shukla, Yogeshwer
Singh, U.
Kalra, N.
Source
Journal of Cancer Epidemiology
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-01-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The majority of squamous cell carcinomas of cervix are preceded by visible changes in the cervix, most often detected by cervical smear.
As cervical cancer is preceded by long precancerous stages, identification of the high-risk population through detection of DNA ploidy may be of importance in effective management of this disease.
Here we attempted to correlate aneuploid DNA patterns and their influence on biological behavior of flow-cytometry analysis of DNA ploidy which was carried out in cytologically diagnosed cases of mild (79), moderate (36), and severe (12) dysplasia, as well as “atypical squamous cells of unknown significance (ASCUS)” (57) along with controls (69), in order to understand its importance in malignant progression of disease.
Cytologically diagnosed dysplasias, which were employed for DNA ploidy studies, 39 mild, 28 moderate, and 11 severe dysplasia cases were found to be aneuploid.
Out of the 69 control subjects, 6 cases showed aneuploidy pattern and the rest 63 subjects were diploid.
An aneuploidy pattern was observed in 8 out of 57 cases of cytologically evaluated ASCUS.
The results of the followup studies showed that aberrant DNA content reliably predicts the occurrence of squamous cell carcinoma in cervical smear.
Flow cytometric analysis of DNA ploidy may provide a strategic diagnostic tool for early detection of carcinoma cervix.
Therefore, it is a concept of an HPV screening with reflex cytology in combination with DNA flow cytometry to detect progressive lesions with the greatest possible sensitivity and specificity.
American Psychological Association (APA)
Singh, Madhulika& Mehrotra, S.& Kalra, N.& Singh, U.& Shukla, Yogeshwer. 2008. Correlation of DNA Ploidy with Progression of Cervical Cancer. Journal of Cancer Epidemiology،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-461520
Modern Language Association (MLA)
Singh, Madhulika…[et al.]. Correlation of DNA Ploidy with Progression of Cervical Cancer. Journal of Cancer Epidemiology No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-461520
American Medical Association (AMA)
Singh, Madhulika& Mehrotra, S.& Kalra, N.& Singh, U.& Shukla, Yogeshwer. Correlation of DNA Ploidy with Progression of Cervical Cancer. Journal of Cancer Epidemiology. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-461520
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461520