The Hedgehog Pathway Conditions the Bone Microenvironment for Osteolytic Metastasis of Breast Cancer
Joint Authors
Das, Shamik
Shevde, Lalita A.
Samant, Rajeev S.
Source
International Journal of Breast Cancer
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The microenvironment at the site of tumor metastasis plays a key role in determining the fate of the metastasizing tumor cells.
This ultimately has a direct impact on the progression of cancer.
Bone is the preferred site of metastasis of breast cancer.
Painful, debilitating osteolytic lesions are formed as a result of crosstalk between breast cancer cells and cells in the bone, predominantly the osteoblasts and osteoclasts.
In this paper, we have discussed the temporal and spatial role of hedgehog (Hh) signaling in influencing the fate of metastatic breast cancer cells in bone.
By virtue of its secreted ligands, the Hh pathway is capable of homotypic and heterotypic signaling and consequently altering the microenvironment in the bone.
We also have put into perspective the therapeutic implications of using Hh inhibitors to prevent and/or treat bone metastases of breast cancer.
American Psychological Association (APA)
Das, Shamik& Samant, Rajeev S.& Shevde, Lalita A.. 2011. The Hedgehog Pathway Conditions the Bone Microenvironment for Osteolytic Metastasis of Breast Cancer. International Journal of Breast Cancer،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-461529
Modern Language Association (MLA)
Das, Shamik…[et al.]. The Hedgehog Pathway Conditions the Bone Microenvironment for Osteolytic Metastasis of Breast Cancer. International Journal of Breast Cancer No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-461529
American Medical Association (AMA)
Das, Shamik& Samant, Rajeev S.& Shevde, Lalita A.. The Hedgehog Pathway Conditions the Bone Microenvironment for Osteolytic Metastasis of Breast Cancer. International Journal of Breast Cancer. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-461529
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461529