The Current State of Knowledge of Hepatic Ischemia-Reperfusion Injury Based on Its Study in Experimental Models
Joint Authors
Jiménez-Castro, M. B.
Ramalho, Fernando S.
Elias-Miró, M.
Casillas-Ramírez, A.
Peralta, C.
Mendes-Braz, M.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-09
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
The present review focuses on the numerous experimental models used to study the complexity of hepatic ischemia/reperfusion (I/R) injury.
Although experimental models of hepatic I/R injury represent a compromise between the clinical reality and experimental simplification, the clinical transfer of experimental results is problematic because of anatomical and physiological differences and the inevitable simplification of experimental work.
In this review, the strengths and limitations of the various models of hepatic I/R are discussed.
Several strategies to protect the liver from I/R injury have been developed in animal models and, some of these, might find their way into clinical practice.
We also attempt to highlight the fact that the mechanisms responsible for hepatic I/R injury depend on the experimental model used, and therefore the therapeutic strategies also differ according to the model used.
Thus, the choice of model must therefore be adapted to the clinical question being answered.
American Psychological Association (APA)
Mendes-Braz, M.& Elias-Miró, M.& Jiménez-Castro, M. B.& Casillas-Ramírez, A.& Ramalho, Fernando S.& Peralta, C.. 2012. The Current State of Knowledge of Hepatic Ischemia-Reperfusion Injury Based on Its Study in Experimental Models. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-461533
Modern Language Association (MLA)
Mendes-Braz, M.…[et al.]. The Current State of Knowledge of Hepatic Ischemia-Reperfusion Injury Based on Its Study in Experimental Models. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-20.
https://search.emarefa.net/detail/BIM-461533
American Medical Association (AMA)
Mendes-Braz, M.& Elias-Miró, M.& Jiménez-Castro, M. B.& Casillas-Ramírez, A.& Ramalho, Fernando S.& Peralta, C.. The Current State of Knowledge of Hepatic Ischemia-Reperfusion Injury Based on Its Study in Experimental Models. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-461533
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461533