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Difficulties and Perspectives of Immunomodulatory Therapy with Mistletoe Lectins and Standardized Mistletoe Extracts in Evidence-Based Medicine
Joint Authors
Hajtó, Tibor
Perjési, Pál
Fodor, Krisztina
Németh, Pèter
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Viscum album preparations are aqueous mistletoe plant extracts used in complementary and alternative medicine as immunomodulators in cancer therapy.
However, evidence of immunological efficacy of mistletoe extracts (MEs) used in clinical trials is often lacking.
Mechanisms involved in anti-tumor properties of ME and mistletoe lectins (MLs) modify both innate and adaptive immune systems, according to animal model experiments.
In the background of these effects, a selective binding of ML on CD75 ganglioside receptors of interleukin 12 (IL-12)-producing macrophages or dendritic cells can play an important role.
Immunological effects of ME correlate with their lectin activity, showing a bell-shaped dose-response curve of efficacy.
Therefore, a correct determination of MLs for the standardization of commercial ME is essential.
However, plant MLs exhibit heterogeneity, which most likely results from post-translational processing.
In addition, amino acid analysis of ML has revealed numerous conservative substitutions along their amino acid sequence.
Consequently, ML research needs new perspectives, and the advantages and disadvantages of purified and biologically better defined ML preparations are also discussed in this article.
American Psychological Association (APA)
Hajtó, Tibor& Fodor, Krisztina& Perjési, Pál& Németh, Pèter. 2011. Difficulties and Perspectives of Immunomodulatory Therapy with Mistletoe Lectins and Standardized Mistletoe Extracts in Evidence-Based Medicine. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-461560
Modern Language Association (MLA)
Hajtó, Tibor…[et al.]. Difficulties and Perspectives of Immunomodulatory Therapy with Mistletoe Lectins and Standardized Mistletoe Extracts in Evidence-Based Medicine. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-461560
American Medical Association (AMA)
Hajtó, Tibor& Fodor, Krisztina& Perjési, Pál& Németh, Pèter. Difficulties and Perspectives of Immunomodulatory Therapy with Mistletoe Lectins and Standardized Mistletoe Extracts in Evidence-Based Medicine. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-461560
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461560