Cecropia pachystachya : A Species with Expressive In Vivo Topical Anti-Inflammatory and In Vitro Antioxidant Effects
Joint Authors
Pinto, Nícolas de Castro Campos
Aragão, Danielle Maria de Oliveira
Castañon, Maria Christina Marques Nogueira
Pacheco, Natália Ramos
Mello da Silva, Josiane
Scio, Elita
Costa, Juliana de Carvalho da
Mendes, Renata de Freitas
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cecropia pachystachya is a species traditionally used in Brazil to treat inflammation.
This work aims to evaluate the topical anti-inflammatory and antioxidant activities of the methanolic extract of C.
pachystachya (CPM) and to perform its chemical fingerprint by HPLC-DAD.
The topical anti-inflammatory activity was evaluated using the mouse models of acute ear inflammation induced by croton oil, arachidonic acid, capsaicin, EPP, phenol, and chronic inflammation induced by multiple application of croton oil.
The in vitro antioxidant effect of CPM was investigated using DPPH, reducing power, β-carotene bleaching, and TBARS assays.
HPLC analysis was performed to quantify the antioxidant phenolics orientin, isoorientin, and chlorogenic acid previously identified in CPM.
CPM exhibited significant anti-inflammatory effect in the acute models, in some cases comparable to the reference drugs.
Histopathological analysis showed a moderate chronic skin anti-inflammatory effect with decrease in vasodilation, edema, cell infiltration, and epidermal hyperproliferation.
It also showed strong in vitro antioxidant activity.
The contents of orientin, isoorientin, and chlorogenic acid were 66.5 ± 1.8, 118.8 ± 0.7, and 5.4 ± 0.2 µg/mg extract, respectively.
The topical anti-inflammatory activity of CPM could be based on its antioxidant properties, although other effects are probably involved, including COX inhibition and other mechanisms.
American Psychological Association (APA)
Pacheco, Natália Ramos& Pinto, Nícolas de Castro Campos& Mello da Silva, Josiane& Mendes, Renata de Freitas& Costa, Juliana de Carvalho da& Aragão, Danielle Maria de Oliveira…[et al.]. 2014. Cecropia pachystachya : A Species with Expressive In Vivo Topical Anti-Inflammatory and In Vitro Antioxidant Effects. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-461584
Modern Language Association (MLA)
Pacheco, Natália Ramos…[et al.]. Cecropia pachystachya : A Species with Expressive In Vivo Topical Anti-Inflammatory and In Vitro Antioxidant Effects. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-461584
American Medical Association (AMA)
Pacheco, Natália Ramos& Pinto, Nícolas de Castro Campos& Mello da Silva, Josiane& Mendes, Renata de Freitas& Costa, Juliana de Carvalho da& Aragão, Danielle Maria de Oliveira…[et al.]. Cecropia pachystachya : A Species with Expressive In Vivo Topical Anti-Inflammatory and In Vitro Antioxidant Effects. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-461584
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461584