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Novel Vitamin D Analogs for Prostate Cancer Therapy
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Prostate cells contain specific receptors for 1α,25-dihydroxyvitamin D [1α,25(OH)2D] or calcitriol, the active form of vitamin D.
1α,25(OH)2D is known to inhibit the proliferation and invasiveness of prostate cancer cells.
These findings support the use of 1α,25(OH)2D for prostate cancer therapy.
However, 1α,25(OH)2D can cause hypercalcemia, analogs of 1α,25(OH)2D that are less calcemic but exhibit potent antiproliferative activity would be attractive as therapeutic agents.
To accomplish these goals, different strategies, based on metabolism, molecular mechanism of actions, and structural modeling, have been taken to modify the structure of vitamin D molecule with the aims to improve the efficacy and decrease the toxicity of vitamin D to treat different diseases.
During the past four decades, over 3,000 analogs have been synthesized.
In this paper, we discuss the development and the biological analysis of a unique class of vitamin D analogs with a substitution at the carbon 2 of 19-nor-1α,25(OH)2D3 molecule for potential application to the prevention and treatment of prostate cancer as well as other cancers.
American Psychological Association (APA)
Chen, Tai C.& Kittaka, Atsushi. 2011. Novel Vitamin D Analogs for Prostate Cancer Therapy. ISRN Urology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-461603
Modern Language Association (MLA)
Chen, Tai C.& Kittaka, Atsushi. Novel Vitamin D Analogs for Prostate Cancer Therapy. ISRN Urology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-461603
American Medical Association (AMA)
Chen, Tai C.& Kittaka, Atsushi. Novel Vitamin D Analogs for Prostate Cancer Therapy. ISRN Urology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-461603
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461603