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Body Pigmentation as a Risk Factor for the Formation of Intracranial Aneurysms
Joint Authors
Schulter, Günter
Papousek, Ilona
Konstantiniuk, Peter
Rübenbauer, Viktoria R.
Leber, Klaus
Kronawetter, Elke
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Recent studies demonstrated pigmented cells both in the murine heart, in pulmonary veins, and in brain arteries.
Moreover, a role for melanocytes in the downregulation of inflammatory processes was suggested.
As there is increasing evidence that inflammation is contributing significantly to the pathogenesis of intracranial aneurysms, melanocyte-like cells may be relevant in preventing age-related impairment of vessels.
As pigmentation of the heart reflects that of coat color, aspects of body pigmentation might be associated with the incidence of intracranial aneurysms.
We performed a case-control study to evaluate associations between the pigmentation of hair and eyes and the formation of aneurysms.
In addition to hair and eye color, constitutive and facultative skin pigmentation were assessed in a replication study as well as individual handedness which can be seen as a neurophysiological correlate of developmental pigmentation processes.
Hair pigmentation was highly associated with intracranial aneurysms in both samples, whereas eye pigmentation was not.
In the replication cohort, facultative but not constitutive skin pigmentation proved significant.
The strongest association was observed for individual handedness.
Results indicate a significant association of intracranial aneurysms with particular aspects of body pigmentation as well as handedness, and imply clinical usefulness for screening of aneurysms and possible interventions.
American Psychological Association (APA)
Schulter, Günter& Leber, Klaus& Kronawetter, Elke& Rübenbauer, Viktoria R.& Konstantiniuk, Peter& Papousek, Ilona. 2014. Body Pigmentation as a Risk Factor for the Formation of Intracranial Aneurysms. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-461615
Modern Language Association (MLA)
Schulter, Günter…[et al.]. Body Pigmentation as a Risk Factor for the Formation of Intracranial Aneurysms. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-461615
American Medical Association (AMA)
Schulter, Günter& Leber, Klaus& Kronawetter, Elke& Rübenbauer, Viktoria R.& Konstantiniuk, Peter& Papousek, Ilona. Body Pigmentation as a Risk Factor for the Formation of Intracranial Aneurysms. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-461615
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461615