Phosphodiesterase Type 4D Gene Polymorphism : Association with the Response to Short-Acting Bronchodilators in Paediatric Asthma Patients
Joint Authors
Brière, Julie
Pastinen, Tomi
Labuda, Malgorzata
Bérubé, Denis
Krajinovic, Maja
Beaulieu, Patrick
Laberge, Sophie
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Short-acting b2-adrenergic receptor agonists are commonly used bronchodilators for symptom relief in asthmatics.
The aim of this study was to test whether genetic variants in PDE4D gene, a key regulator of b2-adrenoceptor-induced cAMP turnover in airway smooth muscle cells, affect the response to short-acting b2-agonists.
Bronchodilator responsiveness was assessed in 133 asthmatic children by % change in baseline forced expiratory volume in one second (FEV1) after administration of albuterol.
The analyses were performed in patients with airway obstruction (FEV1/FVC ratio below 90%, n=93).
FEV1 % change adjusted for baseline FEV1 values was significantly different between genotypes of rs1544791 G/A polymorphism (P=0.006) and −1345 C/T (rs1504982) promoter variation (P=0.03).
The association remained significant with inclusion of age, sex, atopy, and controller medication into multivariate model (P=0.004 and P=0.02, resp.).
Our work identifies new genetic variants implicated in modulation of asthma treatment, one of them (rs1544791) previously associated with asthma phenotype.
American Psychological Association (APA)
Labuda, Malgorzata& Laberge, Sophie& Brière, Julie& Bérubé, Denis& Beaulieu, Patrick& Pastinen, Tomi…[et al.]. 2011. Phosphodiesterase Type 4D Gene Polymorphism : Association with the Response to Short-Acting Bronchodilators in Paediatric Asthma Patients. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-461621
Modern Language Association (MLA)
Labuda, Malgorzata…[et al.]. Phosphodiesterase Type 4D Gene Polymorphism : Association with the Response to Short-Acting Bronchodilators in Paediatric Asthma Patients. Mediators of Inflammation No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-461621
American Medical Association (AMA)
Labuda, Malgorzata& Laberge, Sophie& Brière, Julie& Bérubé, Denis& Beaulieu, Patrick& Pastinen, Tomi…[et al.]. Phosphodiesterase Type 4D Gene Polymorphism : Association with the Response to Short-Acting Bronchodilators in Paediatric Asthma Patients. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-461621
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461621