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Genetic Polymorphisms in Genes Related to Oxidative Stress (GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO, eNOS) and Survival of Rectal Cancer Patients after Radiotherapy
Joint Authors
Hoffmeister, Michael
Risch, Angela
Funke, Silvia
Stegmaier, Christa
Chang-Claude, Jenny
Brenner, Hermann
Seiler, Christoph M.
Nieters, Alexandra
Source
Journal of Cancer Epidemiology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Radiotherapy exerts part of its antineoplastic effect by generating oxidative stress, therefore genetic variation in oxidative stress-related enzymes may influence survival of rectal cancer patients.
We hypothesized that genetic polymorphisms associated with higher amounts of reactive oxygen species (ROS) that exaggerate cytotoxic activity could improve survival after radiotherapy.
We followed 114 rectal cancer patients who received radiotherapy for an average of 42.5 months.
Associations between genotypes (GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO and eNOS) and overall survival were assessed using Kaplan-Meier curves and Cox proportional hazards regression.
As hypothesized, patients carrying low ROS producing eNOS Glu298Asp asparagine allele showed an increased hazard of death compared to homozygous carriers of the glutamine allele (hazard ratio (HR): 2.10, 95% confidence interval (CI): 1.01–4.38).
However, carriers of low ROS producing MPO G463A A allele had a decreased hazard of death compared to patients homozygous for the G allele (HR: 0.44, 95% CI: 0.21–0.93) although patients homozygous for the A allele had a slightly increased hazard (HR: 1.12, 95% CI: 0.25–5.08).
This explorative study provides first results and highlights the need for further, larger studies to investigate association between genetic variation in oxidative stress genes and survival of rectal cancer patients who received radiotherapy.
American Psychological Association (APA)
Funke, Silvia& Risch, Angela& Nieters, Alexandra& Hoffmeister, Michael& Stegmaier, Christa& Seiler, Christoph M.…[et al.]. 2009. Genetic Polymorphisms in Genes Related to Oxidative Stress (GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO, eNOS) and Survival of Rectal Cancer Patients after Radiotherapy. Journal of Cancer Epidemiology،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-461650
Modern Language Association (MLA)
Funke, Silvia…[et al.]. Genetic Polymorphisms in Genes Related to Oxidative Stress (GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO, eNOS) and Survival of Rectal Cancer Patients after Radiotherapy. Journal of Cancer Epidemiology No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-461650
American Medical Association (AMA)
Funke, Silvia& Risch, Angela& Nieters, Alexandra& Hoffmeister, Michael& Stegmaier, Christa& Seiler, Christoph M.…[et al.]. Genetic Polymorphisms in Genes Related to Oxidative Stress (GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO, eNOS) and Survival of Rectal Cancer Patients after Radiotherapy. Journal of Cancer Epidemiology. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-461650
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461650