Efficacy and Safety of Low-Dose Peginterferon Alpha-2a Plus Ribavirin on Chronic Hepatitis C
Joint Authors
Deng, Guohong
Fan, Ke
Wang, Yuming
Wang, Xiaohong
Mao, Qing
Yan, Zehui
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The purpose of this study was to assess the efficacy and safety of low-dose peg-IFN α-2a plus ribavirin on the treatment of patients with chronic hepatitis C virus (HCV) infection.
Patients and Methods.
A total of 243 HCV patients treated with different doses of peg-IFN α-2a plus ribavirin were stratified into three groups.
End-of-treatment response (ETR) and sustained viral response (SVR) were evaluated for efficacy.
Adverse events and laboratory abnormalities were conducted for safety.
Results.
ETR and SVR in group I were obtained in 83.9% and 68.9% of the patients, separately, which was similar to groups II (84.1% and 68.3%) and III (81.7% and 66.7%).
The received peg-IFN α-2a dose was not the independent factor-related SVR in our population (OR, 1.31; 95% CI, 0.94–1.81; P=0.106).
The frequency of no adverse events reported in group III (24.7%) was significantly higher than that in group I (11.5%) and group II (12.7%) (P=0.036).
Conclusions.
The peg-IFN α-2a 90 μg/week plus ribavirin is as effective as, and better tolerated than, peg-IFN α-2a standard dose with ribavirin in the treatment of chronic hepatitis C.
This low-dose combination achieves high SVR rates and may be cost-saving.
American Psychological Association (APA)
Yan, Zehui& Fan, Ke& Wang, Xiaohong& Mao, Qing& Deng, Guohong& Wang, Yuming. 2012. Efficacy and Safety of Low-Dose Peginterferon Alpha-2a Plus Ribavirin on Chronic Hepatitis C. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-461656
Modern Language Association (MLA)
Yan, Zehui…[et al.]. Efficacy and Safety of Low-Dose Peginterferon Alpha-2a Plus Ribavirin on Chronic Hepatitis C. Gastroenterology Research and Practice No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-461656
American Medical Association (AMA)
Yan, Zehui& Fan, Ke& Wang, Xiaohong& Mao, Qing& Deng, Guohong& Wang, Yuming. Efficacy and Safety of Low-Dose Peginterferon Alpha-2a Plus Ribavirin on Chronic Hepatitis C. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-461656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461656