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Age-Dependent Fecal Bacterial Correlation to Inflammatory Bowel Disease for Newly Diagnosed Untreated Children
Joint Authors
Vatn, Morten H.
Perminow, Gøri
Thorkildsen, Lill-Therse
Rudi, Knut
Nwosu, Felix Chinweije
Ricanek, Petr
Avershina, Ekaterina
Brackmann, Stephan
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The knowledge about correlation patterns between the fecal microbiota and inflammatory bowel diseases (IBD)—comprising the two subforms Crohn's disease (CD) and ulcerative colitis (UC)—for newly diagnosed untreated children is limited.
To address this knowledge gap, a selection of faecal specimens (CD, n=27 and UC, n=16) and non-IBD controls (n=30) children (age < 18 years) was analysed utilising bacterial small subunit (SSU) rRNA.
We found, surprising age dependence for the fecal microbiota correlating to IBD.
The most pronounced patterns were that E.
coli was positively (R2=0.16, P=0.05) and Bacteroidetes, negatively (R2=0.15, P=0.05) correlated to age for CD patients.
For UC, we found an apparent opposite age-related disease correlation for both Bacteroides and Escherichia.
In addition, there was an overrepresentation of Haemophilus for the UC children.
From our, results we propose a model where the aetiology of IBD is related to an on-going immunological development in children requiring different age-dependent bacterial stimuli.
The impact of our findings could be a better age stratification for understanding and treating IBD in children.
American Psychological Association (APA)
Nwosu, Felix Chinweije& Thorkildsen, Lill-Therse& Avershina, Ekaterina& Ricanek, Petr& Perminow, Gøri& Brackmann, Stephan…[et al.]. 2013. Age-Dependent Fecal Bacterial Correlation to Inflammatory Bowel Disease for Newly Diagnosed Untreated Children. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-461677
Modern Language Association (MLA)
Nwosu, Felix Chinweije…[et al.]. Age-Dependent Fecal Bacterial Correlation to Inflammatory Bowel Disease for Newly Diagnosed Untreated Children. Gastroenterology Research and Practice No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-461677
American Medical Association (AMA)
Nwosu, Felix Chinweije& Thorkildsen, Lill-Therse& Avershina, Ekaterina& Ricanek, Petr& Perminow, Gøri& Brackmann, Stephan…[et al.]. Age-Dependent Fecal Bacterial Correlation to Inflammatory Bowel Disease for Newly Diagnosed Untreated Children. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-461677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461677