The Role of Oxidative Stress on the Pathogenesis of Graves' Disease
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Graves' disease is a most common cause of hyperthyroidism.
It is an autoimmune disease, and autoimmune process induces an inflammatory reaction, and reactive oxygen species (ROSs) are among its products.
When balance between oxidants and antioxidants is disturbed, in favour of the oxidants it is termed “oxidative stress” (OS).
Increased OS characterizes Graves' disease.
It seems that the level of OS is increased in subjects with Graves' ophthalmopathy compared to the other subjects with Graves' disease.
Among the other factors, OS is involved in proliferation of orbital fibroblasts.
Polymorphism of the 8-oxoG DNA N-glycosylase 1 (hOGG1) involved in repair of the oxidative damaged DNA increases in the risk for developing Grave's disease.
Treatment with glucocorticoids reduces levels of OS markers.
A recent large clinical trial evaluated effect of selenium on mild Graves' ophthalmopathy.
Selenium treatment was associated with an improved quality of life and less eye involvement and slowed the progression of Graves' orbitopathy, compared to placebo.
American Psychological Association (APA)
Žarković, Miloš. 2011. The Role of Oxidative Stress on the Pathogenesis of Graves' Disease. Journal of Thyroid Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-461696
Modern Language Association (MLA)
Žarković, Miloš. The Role of Oxidative Stress on the Pathogenesis of Graves' Disease. Journal of Thyroid Research No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-461696
American Medical Association (AMA)
Žarković, Miloš. The Role of Oxidative Stress on the Pathogenesis of Graves' Disease. Journal of Thyroid Research. 2011. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-461696
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461696