Increased Oxidative Stress and Imbalance in Antioxidant Enzymes in the Brains of Alloxan-Induced Diabetic Rats
Joint Authors
Abelaira, Helena M.
Ceretta, Luciane B.
Quevedo, João
Zappellini, Giovanni
Steckert, Amanda V.
Dal-Pizzol, Felipe
Réus, Gislaine Z.
Felisbino, Francine F.
Ribeiro, Karine F.
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Diabetes Mellitus (DM) is associated with pathological changes in the central nervous system (SNC) as well as alterations in oxidative stress.
Thus, the main objective of this study was to evaluate the effects of the animal model of diabetes induced by alloxan on memory and oxidative stress.
Diabetes was induced in Wistar rats by using a single injection of alloxan (150 mg/kg), and fifteen days after induction, the rats memory was evaluated through the use of the object recognition task.
The oxidative stress parameters and the activity of antioxidant enzymes, superoxide dismutase (SOD), and catalase (CAT) were measured in the rat brain.
The results showed that diabetic rats did not have alterations in their recognition memory.
However, the results did show that diabetic rats had increases in the levels of superoxide in the prefrontal cortex, and in thiobarbituric acid reactive species (TBARS) production in the prefrontal cortex and in the amygdala in submitochondrial particles.
Also, there was an increase in protein oxidation in the hippocampus and striatum, and in TBARS oxidation in the striatum and amygdala.
The SOD activity was decreased in diabetic rats in the striatum and amygdala.
However, the CAT activity was increased in the hippocampus taken from diabetic rats.
In conclusion, our findings illustrate that the animal model of diabetes induced by alloxan did not cause alterations in the animals’ recognition memory, but it produced oxidants and an imbalance between SOD and CAT activities, which could contribute to the pathophysiology of diabetes.
American Psychological Association (APA)
Ceretta, Luciane B.& Réus, Gislaine Z.& Abelaira, Helena M.& Ribeiro, Karine F.& Zappellini, Giovanni& Felisbino, Francine F.…[et al.]. 2012. Increased Oxidative Stress and Imbalance in Antioxidant Enzymes in the Brains of Alloxan-Induced Diabetic Rats. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-461714
Modern Language Association (MLA)
Ceretta, Luciane B.…[et al.]. Increased Oxidative Stress and Imbalance in Antioxidant Enzymes in the Brains of Alloxan-Induced Diabetic Rats. Experimental Diabetes Research No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-461714
American Medical Association (AMA)
Ceretta, Luciane B.& Réus, Gislaine Z.& Abelaira, Helena M.& Ribeiro, Karine F.& Zappellini, Giovanni& Felisbino, Francine F.…[et al.]. Increased Oxidative Stress and Imbalance in Antioxidant Enzymes in the Brains of Alloxan-Induced Diabetic Rats. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-461714
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461714