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Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 Hypertensives
Joint Authors
Varma, Deepti
Williamson, Sheara T.
Jansen, Susan
Brown, Michael D.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Endothelial dysfunction and a sedentary lifestyle may be involved in the development of hypertension which is proliferative among middle-aged African Americans (AA).
Signaling molecules derived from the oxidation of 20-carbon fatty acid molecules known as eicosanoids influence vascular tone.
The relationship between aerobic fitness and eicosanoid formation following exercise in middle-aged African American hypertensives is unknown.
Purpose.
To determine the relationship between aerobic capacity and eicosanoid formation after a bout of moderate-intensity exercise in middle-aged AA hypertensives.
Methods.
Ten sedentary hypertensive AA underwent 50 min of aerobic exercise at 65% VO2max.
Urine was collected for 24 hr on two occasions, prior to testing and immediately following the bout of exercise.
Urinary metabolites of prostacyclin (6-keto PGF1α) and thromboxane (11-dTXB2) were measured during the day and night periods by high-performance liquid chromatography (HPLC).
Results.
6-keto PGF1α levels significantly increased (P=.04) following the bout of exercise compared to the control day.
There was a significant relationship (r=.49, P<.05) between 6-keto PGF1α levels and VO2max during the exercise day.
Conclusion.
Based on this preliminary study, there appears to be a relationship between aerobic capacity and exercise-induced 6-keto PGF1α production in middle-aged hypertensive AAs.
AAs with lower VO2max had lower 6-keto PGF1α formation.
American Psychological Association (APA)
Williamson, Sheara T.& Varma, Deepti& Brown, Michael D.& Jansen, Susan. 2011. Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 Hypertensives. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-461727
Modern Language Association (MLA)
Williamson, Sheara T.…[et al.]. Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 Hypertensives. Journal of Aging Research No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-461727
American Medical Association (AMA)
Williamson, Sheara T.& Varma, Deepti& Brown, Michael D.& Jansen, Susan. Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 Hypertensives. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-461727
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461727