![](/images/graphics-bg.png)
Function of Serum Complement in Drinking Water Arsenic Toxicity
Joint Authors
Nabi, A. H. M. Nurun
Hossain, Mahmud
Zahid, M. Shamim Hasan
Islam, Laila N.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Serum complement function was evaluated in 125 affected subjects suffering from drinking water arsenic toxicity.
Their mean duration of exposure was 7.4±5.3 yrs, and the levels of arsenic in drinking water and urine samples were 216±211 and 223±302 μg/L, respectively.
The mean bactericidal activity of complement from the arsenic patients was 92% and that in the unexposed controls was 99% (P<0.01), but heat-inactivated serum showed slightly elevated activity than in controls.
In patients, the mean complement C3 was 1.56 g/L, and C4 was 0.29 g/L compared to 1.68 g/L and 0.25 g/L, respectively, in the controls.
The mean IgG in the arsenic patients was 24.3 g/L that was highly significantly elevated (P<0.001).
Arsenic patients showed a significant direct correlation between C3 and bactericidal activity (P=0.014).
Elevated levels of C4 indicated underutilization and possibly impaired activity of the classical complement pathway.
We conclude reduced function of serum complement in drinking water arsenic toxicity.
American Psychological Association (APA)
Islam, Laila N.& Zahid, M. Shamim Hasan& Nabi, A. H. M. Nurun& Hossain, Mahmud. 2012. Function of Serum Complement in Drinking Water Arsenic Toxicity. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-461729
Modern Language Association (MLA)
Islam, Laila N.…[et al.]. Function of Serum Complement in Drinking Water Arsenic Toxicity. Journal of Toxicology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-461729
American Medical Association (AMA)
Islam, Laila N.& Zahid, M. Shamim Hasan& Nabi, A. H. M. Nurun& Hossain, Mahmud. Function of Serum Complement in Drinking Water Arsenic Toxicity. Journal of Toxicology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-461729
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461729