Ezetimibe : Its Novel Effects on the Prevention and the Treatment of Cholesterol Gallstones and Nonalcoholic Fatty Liver Disease
Joint Authors
Liu, Min
Neuschwander-Tetri, Brent A.
Wang, David Q.-H.
de Bari, Ornella
Portincasa, Piero
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-03
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The cholesterol absorption inhibitor ezetimibe can significantly reduce plasma cholesterol concentrations by inhibiting the Niemann-Pick C1-like 1 protein (NPC1L1), an intestinal sterol influx transporter that can actively facilitate the uptake of cholesterol for intestinal absorption.
Unexpectedly, ezetimibe treatment also induces a complete resistance to cholesterol gallstone formation and nonalcoholic fatty liver disease (NAFLD) in addition to preventing hypercholesterolemia in mice on a Western diet.
Because chylomicrons are the vehicles with which the enterocytes transport cholesterol and fatty acids into the body, ezetimibe could prevent these two most prevalent hepatobiliary diseases possibly through the regulation of chylomicron-derived cholesterol and fatty acid metabolism in the liver.
It is highly likely that there is an intestinal and hepatic cross-talk through the chylomicron pathway.
Therefore, understanding the molecular mechanisms whereby cholesterol and fatty acids are absorbed from the intestine could offer an efficacious novel approach to the prevention and the treatment of cholesterol gallstones and NAFLD.
American Psychological Association (APA)
de Bari, Ornella& Neuschwander-Tetri, Brent A.& Liu, Min& Portincasa, Piero& Wang, David Q.-H.. 2011. Ezetimibe : Its Novel Effects on the Prevention and the Treatment of Cholesterol Gallstones and Nonalcoholic Fatty Liver Disease. Journal of Lipids،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-461733
Modern Language Association (MLA)
de Bari, Ornella…[et al.]. Ezetimibe : Its Novel Effects on the Prevention and the Treatment of Cholesterol Gallstones and Nonalcoholic Fatty Liver Disease. Journal of Lipids No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-461733
American Medical Association (AMA)
de Bari, Ornella& Neuschwander-Tetri, Brent A.& Liu, Min& Portincasa, Piero& Wang, David Q.-H.. Ezetimibe : Its Novel Effects on the Prevention and the Treatment of Cholesterol Gallstones and Nonalcoholic Fatty Liver Disease. Journal of Lipids. 2011. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-461733
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461733