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Over Ten-Year Kidney Graft Survival Determinants
Joint Authors
Cabrita, António
Dias, Leonídio
Castro Henriques, António
Fonseca, Isabel
Malheiro, Jorge
Almeida, Manuela
Guedes, Anabela Malho
Martins, La Salete
Pedroso, Sofia
Source
International Journal of Nephrology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Kidney graft survival has been mainly evaluated using an up to 10-year threshold.
Instead, in this study our aim was to evaluate predictive variables that impact long-term kidney graft survival (≥10 years).
We enrolled 892 patients in our analysis: 638 patients with functioning graft at 10 years PT and 254 patients with graft failure at 10 years PT (considering patient death with a functioning graft <10 years PT as graft failure).
Between groups comparisons were done using Mann-Whitney and chi-square test.
To determine independent predictive variables for long-term graft survival a multivariate-adjusted logistic regression was performed.
Significant predictors of long term graft survival were lower 12-month PT creatinine (OR=0.26, P<0.001), lower donor age (OR=0.98, P=0.004), shorter time on dialysis (OR=0.93, P=0.044), recipient positive CMV IgG (OR=1.59, P=0.040), absence of AR episodes (OR=1.57, P=0.047), 0 to 1 (versus 2) HLA-B mismatch (OR=1.80, P=0.004), and recipients male gender (OR=1.84, P=0.005).
Our results show that an early KT, younger donor age, and an optimal first year graft function are of paramount importance for long-term graft survival.
Measures that address these issues (careful donor selection, preemptive KT, and effective immunosuppressive protocols) are still warranted.
American Psychological Association (APA)
Guedes, Anabela Malho& Malheiro, Jorge& Fonseca, Isabel& Martins, La Salete& Pedroso, Sofia& Almeida, Manuela…[et al.]. 2012. Over Ten-Year Kidney Graft Survival Determinants. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-461754
Modern Language Association (MLA)
Guedes, Anabela Malho…[et al.]. Over Ten-Year Kidney Graft Survival Determinants. International Journal of Nephrology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-461754
American Medical Association (AMA)
Guedes, Anabela Malho& Malheiro, Jorge& Fonseca, Isabel& Martins, La Salete& Pedroso, Sofia& Almeida, Manuela…[et al.]. Over Ten-Year Kidney Graft Survival Determinants. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-461754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461754